The two facets of gp130 signalling in liver tumorigenesis
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DOI: 10.1007/s00281-021-00861-0
Abstract: The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines… read more here.
Keywords: signalling liver; tumorigenesis; gp130 signalling; liver tumorigenesis ... See more keywords
Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice
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DOI: 10.18632/oncotarget.24583
Abstract: Primary liver cancer is the 3rd leading cause of cancer deaths worldwide with very few effective treatments. Sphingosine kinase 1 (SphK1), a key regulator of sphingolipid metabolites, is over-expressed in human hepatocellular carcinoma (HCC) and… read more here.
Keywords: liver tumorigenesis; deletion; sphk1; sphingosine kinase ... See more keywords
N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets
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DOI: 10.3389/fonc.2021.681366
Abstract: Background A tremendous amount of studies have suggested that post-translational modifications (PTMs) play pivotal roles during tumorigenesis. Compared to other PTMs, lipid modification is less studied. Recently, N-myristoylation, one type of lipid modification, has been… read more here.
Keywords: tumorigenesis; liver tumorigenesis; myristolyation; myristoylation ... See more keywords