Dimensional reduction in complex living systems: Where, why, and how
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100062
Abstract: The unprecedented prowess of measurement techniques provides a detailed, multi‐scale look into the depths of living systems. Understanding these avalanches of high‐dimensional data—by distilling underlying principles and mechanisms—necessitates dimensional reduction. We propose that living systems… read more here.
Keywords: living systems; reduction complex; complex living; dimensional reduction ... See more keywords
Predictive landscapes hidden beneath biological cellular automata.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biological physics"
DOI: 10.1007/s10867-021-09592-7
Abstract: To celebrate Hans Frauenfelder's achievements, we examine energy(-like) "landscapes" for complex living systems. Energy landscapes summarize all possible dynamics of some physical systems. Energy(-like) landscapes can explain some biomolecular processes, including gene expression and, as… read more here.
Keywords: like landscapes; living systems; energy like; cellular automata ... See more keywords
Understanding the significant role of SiOSi bonds: Organosilicon materials as powerful platforms for bioimaging
Sign Up to like & getrecommendations! Published in 2021 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2021.214166
Abstract: Abstract Fluorescence imaging is one of the most powerful methods for the spatial and temporal visualization of bio-species in living systems. Various fluorescent materials have obtained intense and continuous attention, including small-molecule organic fluorophores, luminescent… read more here.
Keywords: role siosi; fluorescent materials; organosilicon materials; significant role ... See more keywords
A near-infrared fluorescent probe for imaging endogenous carbon monoxide in living systems with a large Stokes shift.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2019.03.111
Abstract: Near-infrared (NIR) fluorescent probes with a large Stokes shift are very practical tools for bioimaging applications. Carbon monoxide (CO) is a key gaseous signal molecule and its imaging in living systems has attracted great attention… read more here.
Keywords: stokes shift; fluorescent; near infrared; probe ... See more keywords
Explorability and the origin of network sparsity in living systems
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12521-1
Abstract: The increasing volume of ecologically and biologically relevant data has revealed a wide collection of emergent patterns in living systems. Analysing different data sets, ranging from metabolic gene-regulatory to species interaction networks, we find that… read more here.
Keywords: explorability origin; sparsity living; living systems; explorability ... See more keywords
Multi-cellular engineered living systems: building a community around responsible research on emergence.
Sign Up to like & getrecommendations! Published in 2019 at "Biofabrication"
DOI: 10.1088/1758-5090/ab268c
Abstract: Ranging from miniaturized biological robots to organoids, Multi-Cellular Engineered Living Systems (M-CELS) pose complex ethical and societal challenges. Some of these challenges, such as how to best distribute risks and benefits, are likely to arise… read more here.
Keywords: research; engineered living; living systems; multi cellular ... See more keywords
The hallmarks of living systems: towards creating artificial cells
Sign Up to like & getrecommendations! Published in 2018 at "Interface Focus"
DOI: 10.1098/rsfs.2018.0023
Abstract: Despite the astonishing diversity and complexity of living systems, they all share five common hallmarks: compartmentalization, growth and division, information processing, energy transduction and adaptability. In this review, we give not only examples of how… read more here.
Keywords: living systems; hallmarks living; creating artificial; systems towards ... See more keywords
Free energy and inference in living systems
Sign Up to like & getrecommendations! Published in 2022 at "Interface Focus"
DOI: 10.1098/rsfs.2022.0041
Abstract: Organisms are non-equilibrium, stationary systems self-organized via spontaneous symmetry breaking and undergoing metabolic cycles with broken detailed balance in the environment. The thermodynamic free-energy (FE) principle describes an organism’s homeostasis as the regulation of biochemical… read more here.
Keywords: free energy; energy inference; living systems; inference living ... See more keywords
Effective connectivity determines the critical dynamics of biochemical networks
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2021.0659
Abstract: Living systems comprise interacting biochemical components in very large networks. Given their high connectivity, biochemical dynamics are surprisingly not chaotic but quite robust to perturbations—a feature C.H. Waddington named canalization. Because organisms are also flexible… read more here.
Keywords: living systems; connectivity; dynamical regime; effective connectivity ... See more keywords
Meta synthetic biology: controlling the evolution of engineered living systems
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.13350
Abstract: A major aim of synthetic biology is the design of robust living systems for real‐world applications. In seemingly contrast, evolution changes the living, exploring new survival strategies in response to environmental challenges. How do we… read more here.
Keywords: evolution; biology controlling; living systems; synthetic biology ... See more keywords
Engineering multicellular living systems—a Keystone Symposia report
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14896
Abstract: The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate… read more here.
Keywords: engineering multicellular; systems keystone; living systems; multicellular living ... See more keywords