β-Ionone represses renal cell carcinoma progression through activating LKB1/AMPK-triggered autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23331
Abstract: β-Ionone, the end ring analog of β-carotenoids, has been proven to have an antitumor effect in a variety of cancers. In this study, we investigated the impact of β-ionone on renal cell carcinoma (RCC) cell… read more here.
Keywords: cell; cell carcinoma; renal cell; ionone ... See more keywords
LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-021-00887-3
Abstract: Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling of the ischemic heart. Because little is known about the involvement of long non-coding RNAs (lncRNAs) in regulating cardiac metabolism, we used unbiased transcriptome… read more here.
Keywords: heart; metabolic homeostasis; lkb1 ampk; cardiac metabolic ... See more keywords
Nuciferine Ameliorates Nonesterified Fatty Acid-Induced Bovine Mammary Epithelial Cell Lipid Accumulation, Apoptosis, and Impaired Migration via Activating LKB1/AMPK Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06133
Abstract: High blood concentrations of nonesterified fatty acids (NEFAs) provoke various metabolic disorders and are associated with mammary tissue injury and decreased milk production in dairy cows. Nuciferine, an alkaloid found in Nelumbo nucifera leaves, has… read more here.
Keywords: lipid accumulation; ampk; migration; accumulation apoptosis ... See more keywords
γ-Mangostin ameliorates free fatty acid-induced lipid accumulation via the SIRT1/LKB1/AMPK pathway in HepG2 and L02 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b05632
Abstract: Lipid accumulation is a typical characteristic of nonalcoholic fatty liver disease (NAFLD). The inhibition of lipid accumulation is regarded as a potential treatment for NAFLD. In this study, we investigated the effects of γ-mangostin or… read more here.
Keywords: accumulation; lipid accumulation; sirt1 lkb1; fatty acid ... See more keywords
lncRNA NBR2 attenuates angiotensin II-induced myocardial hypertrophy through repressing ER stress via activating LKB1/AMPK/Sirt1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2062527
Abstract: ABSTRACT Myocardial hypertrophy leads to heart failure (HF), and emerging researchers have illustrated that long noncoding RNAs (lncRNAs) modulate myocardial hypertrophy. Here, we explored the role and mechanism of a novel lncRNA, NBR2, in modulating… read more here.
Keywords: myocardial hypertrophy; hypertrophy; ampk sirt1; lncrna nbr2 ... See more keywords
Acetylshikonin induces autophagy‐dependent apoptosis through the key LKB1‐AMPK and PI3K/Akt‐regulated mTOR signalling pathways in HL‐60 cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17202
Abstract: Acetylshikonin (ASK) is a natural naphthoquinone derivative of traditional Chinese medicine Lithospermum erythrorhyzon. It has been reported that ASK has bactericidal, anti‐inflammatory and antitumour effects. However, whether ASK induces apoptosis and autophagy in acute myeloid… read more here.
Keywords: lkb1 ampk; apoptosis; medicine; akt ... See more keywords
LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/8730816
Abstract: Inactivating mutations of the tumor suppressor gene Liver Kinase B1 (LKB1) are frequently detected in non-small-cell lung cancer (NSCLC) and cervical carcinoma. Moreover, LKB1 expression is epigenetically regulated in several tumor types. LKB1 has an… read more here.
Keywords: lkb1 ampk; response; lkb1; cancer ... See more keywords
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6196173
Abstract: Myocardial ischemia/reperfusion injury (I/RI) is closely associated with energy substrate metabolism. Fibronectin 1 (Fn1) was markedly elevated in the heart of I/R pigs and ischemic patients, but its role in myocardial I/RI is controversial and… read more here.
Keywords: reperfusion injury; fibronectin; myocardial ischemia; lkb1 ampk ... See more keywords
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Aging and Disease"
DOI: 10.14336/ad.2017.0517
Abstract: SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson’s disease (PD).… read more here.
Keywords: rotenone; ampk mtor; lkb1 ampk; rotenone induced ... See more keywords
Jingfang Granules improve glucose metabolism disturbance and inflammation in mice with urticaria by up-regulating LKB1/AMPK/SIRT1 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4185813
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Jingfang Granule (JFG) is a classical traditional Chinese medicine prescription to empirically treat skin disease such as urticaria in clinical practice. However, the potential mechanisms of JFG on urticaria are not fully defined.… read more here.
Keywords: inflammation; ampk sirt1; sirt1 axis; mice urticaria ... See more keywords
An Antioxidant Role by Minocycline Via Enhancing the Activation of LKB1/AMPK Signaling in the Process of Cerebral Ischemia Injury.
Sign Up to like & getrecommendations! Published in 2018 at "Current molecular medicine"
DOI: 10.2174/1566524018666180907161504
Abstract: BACKGROUND LKB1/AMPK signaling pathway, as a metabolic checkpoint, is involved in the pathogenesis of cerebral ischemia injury. Minocycline, a tetracycline derivative, protects against cerebral ischemia via reducing inflammation, oxidative stress, and apoptosis. The aim of… read more here.
Keywords: ischemia injury; cerebral ischemia; ischemia; lkb1 ampk ... See more keywords