LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma.
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DOI: 10.1158/0008-5472.can-18-3527
Abstract: In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK). Here we investigated the biological consequences of these co-occurring alterations and explored whether… read more here.
Keywords: lung adenocarcinoma; kras mutant; lkb1 keap1; mutant lung ... See more keywords