PARP inhibition induces synthetic lethality and adaptive immunity in LKB1-mutant lung cancer.
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DOI: 10.1158/0008-5472.can-22-1740
Abstract: Contradictory characteristics of elevated mutational burden and a "cold" tumor microenvironment (TME) coexist in LKB1-mutant non-small cell lung cancers (NSCLC). The molecular basis underlying this paradox and strategies tailored to these historically difficult-to-treat cancers are… read more here.
Keywords: inhibition; lkb1 mutant; lung; synthetic lethality ... See more keywords
Abstract 16: The role of innate and adaptive immunity in the sex bias of LKB1-mutant lung adenocarcinoma
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DOI: 10.1158/1538-7445.am2023-16
Abstract: The tumor suppressor gene, LKB1/STK11, is one of the most frequently mutated genes in lung adenocarcinoma (LUAD). A multidimensional analysis of TCGA-LUAD patient data indicates that LKB1 mutation is one of the top sex-biased mutations,… read more here.
Keywords: lkb1 mutant; sex; sex bias; lung adenocarcinoma ... See more keywords
Abstract A027: Defining the role of PER1 and circadian rhythm dysregulation in KRAS/LKB1-mutant lung adenocarcinoma
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DOI: 10.1158/1557-3125.ras23-a027
Abstract: KRAS and LKB1 are frequently co-mutated in lung adenocarcinoma and characterize a particularly aggressive, metastatic, and treatment-resistant subtype of this disease. We recently published that the outputs of biological rhythm pathways downstream of the AMPK… read more here.
Keywords: lkb1 mutant; kras lkb1; per1; lung adenocarcinoma ... See more keywords
Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma.
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DOI: 10.1172/jci.insight.90487
Abstract: Loss of LKB1 activity is prevalent in KRAS mutant lung adenocarcinoma and promotes aggressive and treatment-resistant tumors. Previous studies have shown that LKB1 is a negative regulator of the focal adhesion kinase (FAK), but in… read more here.
Keywords: lung adenocarcinoma; lkb1 mutant; treatment; kras lkb1 ... See more keywords
The Prognostic Model and Drug Sensitivity of LKB1-Mutant Lung Adenocarcinoma Based on Immune Landscape
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DOI: 10.3389/fmolb.2022.756772
Abstract: Background: Lung cancer is the most common cause of cancer-related deaths worldwide. LKB1-mutant lung adenocarcinoma (LUAD) is a unique subtype of this deadly cancer. LKB1 mutations cause functional changes in a variety of cell processes,… read more here.
Keywords: lkb1 mutant; lung; risk; model ... See more keywords