Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader
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DOI: 10.1021/acs.jmedchem.3c01765
Abstract: Nuclear receptor-binding SET domain-containing 2 (NSD2), a methyltransferase that primarily installs the dimethyl mark on lysine 36 of histone 3 (H3K36me2), has been recognized as a promising therapeutic target against cancer. However, existing NSD2 inhibitors… read more here.
Keywords: potent selective; llc0424 potent; llc0424; degrader ... See more keywords