Microglial‐induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23243
Abstract: Norgestrel, a progesterone analogue, has demonstrated neuroprotective effects in a mouse model of retinitis pigmentosa. Neuroprotection is achieved in part through Norgestrels anti‐inflammatory properties, alleviating detrimental microglial activity. Gliosis is a feature of many neurodegenerative… read more here.
Keywords: ller; gliosis; retinitis pigmentosa; cell gliosis ... See more keywords
Compensatory engulfment and Müller glia reactivity in the absence of microglia.
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24182
Abstract: Microglia are known for important phagocytic functions in the vertebrate retina. Reports also suggest that Müller glia have phagocytic capacity, though the relative levels and contexts in which this occurs remain to be thoroughly examined.… read more here.
Keywords: ller; engulfment; ller glia; absence microglia ... See more keywords
Retinal regions shape human and murine Müller cell proteome profile and functionality
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24283
Abstract: The human macula is a highly specialized retinal region with pit‐like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly… read more here.
Keywords: cell; retinal regions; ller; ller cell ... See more keywords
Hydrogen peroxide modulates energy metabolism and oxidative stress in cultures of permanent human Müller cells MIO-M1.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biophotonics"
DOI: 10.1002/jbio.201600201
Abstract: In this study the influence of hydrogen peroxide (H2 O2 ) on the redox state, NADH protein binding, and mitochondrial membrane potential in Müller cells is investigated. Cultures of permanent human Müller cells MIO-M1 were… read more here.
Keywords: cultures permanent; ller; human ller; hydrogen peroxide ... See more keywords
Thioredoxin 1 overexpression attenuated diabetes‐induced endoplasmic reticulum stress in Müller cells via apoptosis signal‐regulating kinase 1
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30378
Abstract: As one of the common and serious chronic complications of diabetes mellitus (DM), the related mechanism of diabetic retinopathy (DR) has not been fully understood. Müller cell reactive gliosis is one of the early pathophysiological… read more here.
Keywords: apoptosis signal; ller; overexpression; signal regulating ... See more keywords
Human glial müller and umbilical vein endothelial cell coculture as an in vitro model to investigate retinal oxidative damage. A morphological and molecular assessment
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24284
Abstract: The aim of this study was to optimize a coculture in vitro model established between the human Müller glial cells and human umbilical vein endothelial cells, mimicking the inner blood‐retinal barrier, and to explore its… read more here.
Keywords: cell; ller; model; coculture ... See more keywords
Release of VAMP5‐positive extracellular vesicles by retinal Müller glia in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12254
Abstract: Cell-cell interactions in the central nervous system are based on the release of molecules mediating signal exchange and providing structural and trophic support through vesicular exocytosis and the formation of extracellular vesicles. The specific mechanisms… read more here.
Keywords: vivo; extracellular vesicles; ller; retinal ller ... See more keywords
Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4707-y
Abstract: Aims/hypothesisRecent studies suggest that abnormal function in Müller glial cells plays an important role in the pathogenesis of diabetic retinopathy. This is associated with the selective accumulation of the acrolein-derived advanced lipoxidation end-product, Nε-(3-formyl-3,4-dehydropiperidino)lysine (FDP-lysine),… read more here.
Keywords: ller; diabetic retinopathy; cell; acrolein scavenging ... See more keywords
The role of Müller cell glucocorticoid signaling in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-019-04521-w
Abstract: Diabetic retinopathy (DR) is a sight-threatening complication associated with the highly prevalent diabetes disorder. Both the microvascular damage and neurodegeneration detected in the retina caused by chronic hyperglycemia have brought special attention to Müller cells,… read more here.
Keywords: ller; diabetic retinopathy; role ller; glucocorticoid signaling ... See more keywords
Probucol promotes high glucose-induced proliferation and inhibits apoptosis by reducing reactive oxygen species generation in Müller cells
Sign Up to like & getrecommendations! Published in 2019 at "International Ophthalmology"
DOI: 10.1007/s10792-019-01130-8
Abstract: PurposeTo explore the protective effect of probucol on human retinal Müller cells cultured in high glucose.MethodsPrimary Müller cells from human retinas were cultured in complete DMEM. Third-generation Müller cells were identified using glutamine synthetase (GS)… read more here.
Keywords: ller; proliferation; ller cells; high glucose ... See more keywords
Müller Glia-Mediated Retinal Regeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02274-w
Abstract: Müller glia originate from neuroepithelium and are the principal glial cells in the retina. During retinal development, Müller glia are one of the last cell types to be born. In lower vertebrates, such as zebrafish,… read more here.
Keywords: glia reprogramming; ller; retinal regeneration; ller glia ... See more keywords