Microglial‐induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa
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DOI: 10.1002/glia.23243
Abstract: Norgestrel, a progesterone analogue, has demonstrated neuroprotective effects in a mouse model of retinitis pigmentosa. Neuroprotection is achieved in part through Norgestrels anti‐inflammatory properties, alleviating detrimental microglial activity. Gliosis is a feature of many neurodegenerative… read more here.
Keywords: ller; gliosis; retinitis pigmentosa; cell gliosis ... See more keywords
Retinal regions shape human and murine Müller cell proteome profile and functionality
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DOI: 10.1002/glia.24283
Abstract: The human macula is a highly specialized retinal region with pit‐like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly… read more here.
Keywords: cell; retinal regions; ller; ller cell ... See more keywords
TNFα activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108353
Abstract: Mouse Müller cells, considered as dormant retinal progenitors, often respond to retinal injury by undergoing reactive gliosis rather than displaying neural regenerative responses. Tumor necrosis factor alpha (TNFα) is a key cytokines induced after injury… read more here.
Keywords: ller; tnf; cell proliferation; mouse ller ... See more keywords
TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy.
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DOI: 10.1016/j.lfs.2020.118988
Abstract: AIMS Diabetic retinopathy (DR) can cause vision loss in patients with diabetes. The present study evaluated the expression of thioredoxin interacting protein (TXNIP) and investigated the role of TXNIP in autophagy and apoptosis of DR.… read more here.
Keywords: autophagy apoptosis; ller cell; txnip; cell ... See more keywords
MÜLLER CELL CONE–ASSOCIATED FOVEAL DETACHMENT AS A RISK FACTOR FOR VISUAL ACUITY LOSS AFTER GLAUCOMA FILTERING SURGERY
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DOI: 10.1097/iae.0000000000003216
Abstract: Supplemental Digital Content is Available in the Text. Enhanced retinal thickness in eyes with intraocular hypotension may cause traction on the Müller cell cone. Combined intraocular hypotension–associated retinal edema and epiretinal membrane may exacerbate the… read more here.
Keywords: filtering surgery; visual acuity; acuity loss; cell cone ... See more keywords
AUTOSOMAL DOMINANT MÜLLER CELL SHEEN DYSTROPHY
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DOI: 10.1097/iae.0000000000003413
Abstract: Supplemental Digital Content is Available in the Text. Müller Cell Sheen Dystrophy is a rare genetic disease with distinct clinical, tomographic, and histopathologic characteristics. We report the findings in a family with 30-year follow-up and… read more here.
Keywords: dystrophy; ller; ller cell; autosomal dominant ... See more keywords
Blocking IL-17A Alleviates Diabetic Retinopathy in Rodents
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DOI: 10.1159/000460514
Abstract: Background/Aims: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune diabetes. This… read more here.
Keywords: mab anti; diabetic retinopathy; anti 17a; ller cell ... See more keywords
Intravitreal slow-release dexamethasone alleviates traumatic proliferative vitreoretinopathy by inhibiting persistent inflammation and Müller cell gliosis in rabbits.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2023.01.04
Abstract: AIM To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy (PVR) and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular trauma. METHODS… read more here.
Keywords: ller cell; pvr; cell gliosis;
Redox and Calcium Alterations of a Müller Cell Line Exposed to Diabetic Retinopathy-Like Environment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.862325
Abstract: Diabetic retinopathy (DR) is a common complication of diabetes mellitus and is the major cause of vision loss in the working-age population. Although DR is traditionally considered a microvascular disease, an increasing body of evidence… read more here.
Keywords: diabetic retinopathy; ller cell; cell; cell line ... See more keywords
VEGF Mediates Retinal Müller Cell Viability and Neuroprotection through BDNF in Diabetes
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DOI: 10.3390/biom11050712
Abstract: To investigate the mechanism of vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) in Müller cell (MC) viability and neuroprotection in diabetic retinopathy (DR), we examined the role of VEGF in MC viability… read more here.
Keywords: viability; bdnf production; ller cell; neuroprotection ... See more keywords