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   Articles with "ller glia" as a keyword



NFkB‐signaling promotes glial reactivity and suppresses Müller glia‐mediated neuron regeneration in the mammalian retina

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24181

Abstract: Müller glia (MG) in mammalian retinas are incapable of regenerating neurons after damage, whereas the MG in lower vertebrates regenerate functional neurons. Identification of cell signaling pathways and gene regulatory networks that regulate MG‐mediated regeneration… read more here.

Keywords: regeneration; ller glia; glia; damage ... See more keywords

Compensatory engulfment and Müller glia reactivity in the absence of microglia.

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24182

Abstract: Microglia are known for important phagocytic functions in the vertebrate retina. Reports also suggest that Müller glia have phagocytic capacity, though the relative levels and contexts in which this occurs remain to be thoroughly examined.… read more here.

Keywords: ller; engulfment; ller glia; absence microglia ... See more keywords

Pten associates with important gene regulatory network to fine‐tune Müller glia‐mediated zebrafish retina regeneration

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24270

Abstract: Unlike mammals, zebrafish possess a remarkable ability to regenerate damaged retina after an acute injury. Retina regeneration in zebrafish involves the induction of Müller glia‐derived progenitor cells (MGPCs) exhibiting stem cell‐like characteristics, which are capable… read more here.

Keywords: zebrafish retina; ller glia; retina; retina regeneration ... See more keywords

Regulating the formation of Müller glia‐derived progenitor cells in the retina

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recommendations! Published in 2024 at "Glia"

DOI: 10.1002/glia.24635

Abstract: We summarize recent findings in different animal models regarding the different cell‐signaling pathways and gene networks that influence the reprogramming of Müller glia into proliferating, neurogenic progenitor cells in the retina. Not surprisingly, most of… read more here.

Keywords: cells retina; ller; progenitor cells; ller glia ... See more keywords

Spontaneously Immortalised Nonhuman Primate Müller Glia Cell Lines as Source to Explore Retinal Reprogramming Mechanisms for Cell Therapies

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recommendations! Published in 2024 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.31482

Abstract: Cell replacement therapies for ocular diseases characterised by photoreceptors degeneration are challenging due to poor primary cell survival in culture. A stable retinal cell source to replace lost photoreceptors holds promise. Müller glia cells play… read more here.

Keywords: glia cell; culture; cell; ller glia ... See more keywords

Modeling of Photoreceptor Donor‐Host Interaction Following Transplantation Reveals a Role for Crx, Müller Glia, and Rho/ROCK Signaling in Neurite Outgrowth

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recommendations! Published in 2019 at "STEM CELLS"

DOI: 10.1002/stem.2985

Abstract: The goal of photoreceptor transplantation is to establish functional synaptic connectivity between donor cells and second‐order neurons in the host retina. There is, however, limited evidence of donor‐host photoreceptor connectivity post‐transplant. In this report, we… read more here.

Keywords: donor host; ller glia; donor; neurite outgrowth ... See more keywords

Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions.

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recommendations! Published in 2018 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-3-319-75402-4_37

Abstract: Within the mammalian retina, both Müller glia and astrocytes display reactivity in response to many forms of retinal injury and disease in a process termed gliosis. Reactive gliosis is a complex process that is considered… read more here.

Keywords: response; ller glia; pathological conditions; gliosis ... See more keywords

Müller Glia-Mediated Retinal Regeneration.

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recommendations! Published in 2021 at "Molecular neurobiology"

DOI: 10.1007/s12035-020-02274-w

Abstract: Müller glia originate from neuroepithelium and are the principal glial cells in the retina. During retinal development, Müller glia are one of the last cell types to be born. In lower vertebrates, such as zebrafish,… read more here.

Keywords: glia reprogramming; ller; retinal regeneration; ller glia ... See more keywords

The miR-216a-Dot1l Regulatory Axis Is Necessary and Sufficient for Müller Glia Reprogramming during Retina Regeneration

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.07.061

Abstract: SUMMARY Unlike the adult mammalian retina, Müller glia (MG) in the adult zebrafish retina are able to dedifferentiate into a ‘‘stem cell’’-like state and give rise to multipotent progenitor cells upon retinal damage. We show… read more here.

Keywords: ller glia; retina regeneration; mir 216a; regeneration ... See more keywords

Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-58290-8

Abstract: Individuals with retinal degenerative diseases struggle to restore vision due to the inability to regenerate retinal cells. Unlike cold-blooded vertebrates, mammals lack Müller glia (MG)-mediated retinal regeneration, indicating the limited regenerative capacity of mammalian MG.… read more here.

Keywords: prox1; transfer; ller glia; regeneration ... See more keywords

MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-11112-4

Abstract: Retinal degenerative diseases ultimately result into irreversible photoreceptor death or loss. At present, the most promising treatment for these diseases is cell replacement therapy. Müller glia are the major glia in the retina, displaying cardinal… read more here.

Keywords: ller; glia derived; ller glia; mir ... See more keywords