Limitations of principal components in quantitative genetic association models for human studies
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DOI: 10.7554/elife.79238
Abstract: Principal Component Analysis (PCA) and the Linear Mixed-effects Model (LMM), sometimes in combination, are the most common genetic association models. Previous PCA-LMM comparisons give mixed results, unclear guidance, and have several limitations, including not varying… read more here.
Keywords: association models; genetic association; association; principal components ... See more keywords