Lamin A/C Cardiomyopathy: Implications for Treatment
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DOI: 10.1007/s11886-019-1224-7
Abstract: The purpose of this review is to provide an update on lamin A/C (LMNA)-related cardiomyopathy and discuss the current recommendations and progress in the management of this disease. LMNA-related cardiomyopathy, an inherited autosomal dominant disease,… read more here.
Keywords: implications treatment; cardiomyopathy implications; lamin cardiomyopathy; lmna related ... See more keywords
PDGF pathway in LMNA-related dilated cardiomyopathy
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DOI: 10.1038/s41569-019-0246-6
Abstract: Activation of the PDGF pathway is involved in the pathogenesis of dilated cardiomyopathy caused by mutations in LMNA; this new finding suggests that inhibition of PDGFRβ is a novel therapeutic target for patients with this… read more here.
Keywords: cardiology; lmna related; pathway lmna; pdgf pathway ... See more keywords
Efficacy and Safety of ARRY-371797 in LMNA-Related Dilated Cardiomyopathy: A Phase 2 Study
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DOI: 10.1161/circgen.122.003730
Abstract: Background: Lamin A/C gene (LMNA)-related dilated cardiomyopathy is a serious and life-threatening condition with a high unmet medical need. This phase 2 study assessed the effects of the oral selective p38 mitogen-activated protein kinase inhibitor… read more here.
Keywords: arry 371797; lmna related; related dilated; phase study ... See more keywords
Characterization of cardiac involvement in children with LMNA-related muscular dystrophy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1142937
Abstract: Introduction: LMNA-related muscular dystrophy is a rare entity that produce “laminopathies” such as Emery–Dreifuss muscular dystrophy (EDMD), limb–girdle muscular dystrophy type 1B (LGMD1B), and LMNA-related congenital muscular dystrophy (L-CMD). Heart failure, malignant arrhythmias, and sudden… read more here.
Keywords: dystrophy; lmna related; muscular dystrophy; related muscular ... See more keywords