Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.
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DOI: 10.1021/acsmedchemlett.6b00496
Abstract: Building upon the success of bortezomib (VELCADE) and carfilzomib (KYPROLIS), the design of a next generation of inhibitors targeting specific subunits within the immunoproteasome is of interest for the treatment of autoimmune disease. There are… read more here.
Keywords: low molecular; highly selective; molecular mass; lmp2 ... See more keywords