LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway
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DOI: 10.1002/2211-5463.12964
Abstract: Lemur tyrosine kinase 3 (LMTK3) is a key member of the serine–threonine tyrosine kinase family. It plays an important role in breast cancer tumorigenesis and progression. However, its biological role in bladder cancer remains elusive.… read more here.
Keywords: bladder cancer; erk mapk; lmtk3; cancer cells ... See more keywords
LMTK3 confers chemo-resistance in breast cancer
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DOI: 10.1038/s41388-018-0197-0
Abstract: Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, chromatin remodeling as well as innate and… read more here.
Keywords: cancer; resistance breast; lmtk3; breast cancer ... See more keywords
Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway.
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DOI: 10.1080/21655979.2021.1974655
Abstract: As an oncogenic kinase in multiple cancers, LMTK3 was deeply implicated in cancer pathogenesis. Nevertheless, its biological function in colorectal cancer (CRC) is still unclear. In this study, LMTK3 mRNA expression was assessed by RT-qPCR.… read more here.
Keywords: erk mapk; colorectal cancer; lmtk3; crc ... See more keywords
The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor
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DOI: 10.3390/ijms24010865
Abstract: Recently, the oncogenic role of lemur tyrosine kinase 3 (LMTK3) has been well established in different tumor types, highlighting it as a viable therapeutic target. In the present study, using in vitro and cell-based assays… read more here.
Keywords: lmtk3; c36; inhibitory properties; kinase ... See more keywords