RNF38 promotes gilteritinib resistance in acute myeloid leukemia via inducing autophagy by regulating ubiquitination of LMX1A
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09936-8
Abstract: Gilteritinib is a commonly used targeted drug for acute myeloid leukemia (AML), but the emergence of gilteritinib resistance greatly reduces the therapeutic effect. RING finger protein 38 (RNF38), a protein with RING Finger domain and… read more here.
Keywords: gilteritinib resistance; resistance; aml cells; lmx1a ... See more keywords
Injury to dopaminergic neurons development via the Lmx1a/Wnt1 autoregulatory loop induced by simazine.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.07.026
Abstract: Simazine is a kind of persistent organic pollutant that is detected in both ground and water and has several routes of exposure. Here, we explored the mechanisms underlying simazine-related effects on dopaminergic neurons via development-related… read more here.
Keywords: simazine; lmx1a; dopaminergic neurons; development ... See more keywords