In Vitro Silencing of lncRNAs Using LNA GapmeRs.
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DOI: 10.1007/978-1-0716-1581-2_10
Abstract: Despite substantial advancements have been achieved in the identification of long noncoding RNA (lncRNA) molecules, many challenges still remain into their functional characterization. Loss-of-function approaches are needed to study oncogenic lncRNAs, which appear more difficult… read more here.
Keywords: silencing lncrnas; vitro silencing; lna gapmers; biology ... See more keywords
An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy
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DOI: 10.3390/molecules26113414
Abstract: The increase in antibacterial resistance is a serious challenge for both the health and defence sectors and there is a need for both novel antibacterial targets and antibacterial strategies. RNA degradation and ribonucleases, such as… read more here.
Keywords: lna gapmers; translation; rne mrna; coli rne ... See more keywords