Influence of LNA modifications on the activity of the 10–23 DNAzyme
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DOI: 10.1039/d5ra00161g
Abstract: The 10–23 DNAzyme is a catalytic DNA molecule that efficiently cleaves RNA in the presence of divalent cations such as Mg2+ or Ca2+. Following their discovery, the 10–23 DNAzymes demonstrated numerous advantages that quickly led… read more here.
Keywords: lna modified; dnazyme; influence lna; lna modifications ... See more keywords
Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes
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DOI: 10.1093/nar/gkac569
Abstract: Abstract G-quadruplexes (G4s) are well known non-canonical DNA secondary structures that can form in human cells. Most of the tools available to investigate G4-biology rely on small molecule ligands that stabilise these structures. However, the… read more here.
Keywords: lna modified; modified oligonucleotide; lna; short lna ... See more keywords