Evaluating the effect of secretome of human amniotic mesenchymal stromal cells on apoptosis induction and epithelial‐mesenchymal transition inhibition in LNCaP prostate cancer cells based on 2D and 3D cell culture models
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3654
Abstract: Prostate cancer (PCa) is the second most prevalent cancer in men worldwide. Most cases of death from PCa are due to metastasis. Early stages of metastasis are mediated by epithelial‐mesenchymal transition (EMT) process through which… read more here.
Keywords: lncap; prostate cancer; cancer cells; cancer ... See more keywords
Differential expression of AP-1 transcription factors in human prostate LNCaP and PC-3 cells: role of Fra-1 in transition to CRPC status
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3012-2
Abstract: Androgen receptor (AR) signaling axis plays a vital role in the development of prostate and critical in the progression of prostate cancer. Androgen withdrawal initially regresses tumors but eventually develops into aggressive castration-resistant prostate cancer… read more here.
Keywords: transition; androgen; lncap cells; lncap ... See more keywords
PO-385 DNA methylation profile of castration-resistant prostate cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.412
Abstract: Introduction Androgen deprivation (AD) therapy is the principle treatment for high-risk locally advanced or metastatic prostate cancer. A significant number of patients develop resistance to this therapy leading to castration resistant prostate cancer (CRPC). A… read more here.
Keywords: methylation; lncap; expression; prostate cancer ... See more keywords
Abstract B003: NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2017-b003
Abstract: Advanced-stage prostate cancer is characterized by osseous metastases whose establishment involves the dynamic interplay of factors and exchange of cellular contents by constituents of the tumor bony microenvironment. Among the factors that transport cellular cargoes… read more here.
Keywords: gls; lncap; prostate cancer; model ... See more keywords
Diverse effects of phospholipase A2 receptor expression on LNCaP and PC-3 prostate cancer cell growth in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26316
Abstract: Physiological and pathophysiological functions of the phospholipase A2 receptor 1 (PLA2R1) are still not completely understood. To elucidate PLA2R1’s function in prostate carcinoma, the receptor was ectopically overexpressed in LNCaP with silenced PLA2R1, and diminished… read more here.
Keywords: prostate; lncap; expression; receptor ... See more keywords
Acute hypoxia induces apoptosis in serum-deprived prostate cancer LNCaP cells
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/16775
Abstract: Background: Human prostate cancer LNCaP cells can develop an androgen-sensitive prostate cancer animal model that closely mimic clinical disease. However, implantation of LNCaP cells yields a low take rate when subcutaneously xenografted in immunodeficient mice.… read more here.
Keywords: lncap cells; acute hypoxia; lncap; prostate cancer ... See more keywords
Effects of Curcumin Combined With the 5-alpha Reductase Inhibitor Dutasteride on LNCaP Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "In Vivo"
DOI: 10.21873/invivo.12396
Abstract: Background/Aim: Curcumin is a natural compound of turmeric, which inhibits prostate cancer cell proliferation. This study examined whether treatment of LNCaP prostate cancer cells with the combination of curcumin and dutasteride, a 5-alpha reductase inhibitor,… read more here.
Keywords: lncap; dutasteride; prostate cancer; cancer cells ... See more keywords
STEAP1 regulation and its influence modulating the response of LNCaP prostate cancer cells to bicalutamide, enzalutamide and apalutamide
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2023.12939
Abstract: Anti-androgen drugs are the standard pharmacological therapies for treatment of non-metastatic prostate cancer (PCa). However, the response of PCa cells may depend on the anti-androgen used and often patients become resistant to treatment. Thus, studying… read more here.
Keywords: anti androgen; lncap; prostate; expression ... See more keywords
Small interfering RNA targeting N-cadherin regulates cell proliferation and migration in enzalutamide-resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13210
Abstract: Enzalutamide is one of the options for treating patients with castration-resistant or metastatic prostate cancer. However, a substantial proportion of patients become resistant to enzalutamide after a period of treatment. Cells in these tumors typically… read more here.
Keywords: cell; prostate cancer; lncap; expression ... See more keywords