Naringenin‐Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25729
Abstract: Prostate cancer is the most common cancer in men and the second most common cause of cancer‐related deaths in men. Although, various drugs targeting the androgen receptor are normally used, the patients frequently undergo recurrence… read more here.
Keywords: lncap cells; prostate cancer; cancer cells; cancer ... See more keywords
Differential expression of AP-1 transcription factors in human prostate LNCaP and PC-3 cells: role of Fra-1 in transition to CRPC status
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3012-2
Abstract: Androgen receptor (AR) signaling axis plays a vital role in the development of prostate and critical in the progression of prostate cancer. Androgen withdrawal initially regresses tumors but eventually develops into aggressive castration-resistant prostate cancer… read more here.
Keywords: transition; androgen; lncap cells; lncap ... See more keywords
Photophysical properties and photocytotoxicity of free and liposome-entrapped diazepinoporphyrazines on LNCaP cells under normoxic and hypoxic conditions.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.064
Abstract: 5,7-Diaryl-substituted symmetrical diazepinoporphyrazine and tribenzodiazepinoporphyrazine were synthesized and characterized using UV-Vis, MS MALDI, and various NMR techniques. The expected photosensitizing potentials of these porphyrazines were evaluated by measuring their abilities to generate singlet oxygen in… read more here.
Keywords: properties photocytotoxicity; photocytotoxicity free; lncap cells; hypoxic conditions ... See more keywords
PO-017 Androgen deprivation and oxidative phosporylation inhibition pose synergistic antitumor effects in subsets of prostate tumours in vitro
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.552
Abstract: Introduction Cancer cells are able to survive oxidative phosphorylation (OXPHOS) inhibition by up-regulation of glycolysis. Androgens stimulate glycolysis in prostate cancer cells through activation of the androgen receptor (AR). Here we hypothesise that androgens might… read more here.
Keywords: cell viability; oxphos inhibition; addition; lncap cells ... See more keywords
Abstract 3983: Direct contact of heterogeneous fibroblasts with cancer cells regulates the invasive phenotype of prostate cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-3983
Abstract: In the tumor microenvironment of prostate cancer (PCa), cancer cells frequently invade the surrounding stroma in the way of single cell migration (SCM) or collective cell migration (CCM). This phenomenon can be responsible for the… read more here.
Keywords: lncap cells; pca cells; pcprf; cancer cells ... See more keywords
The metabolic role of PFKFB4 in androgen-independent growth in vitro and PFKFB4 expression in human prostate cancer tissue
Sign Up to like & getrecommendations! Published in 2020 at "BMC Urology"
DOI: 10.1186/s12894-020-00635-0
Abstract: Background It is well known that androgen-deprivation therapy (ADT) can inevitably drive prostate cancer (PCa) cells into a castration-resistant state. According to the “Warburg effect”, the metabolism of aggressive tumor cells increases significantly. The growth… read more here.
Keywords: lncap cells; pfkfb4 expression; tissue; pfkfb4 ... See more keywords
Abiraterone and MDV3100 inhibits the proliferation and promotes the apoptosis of prostate cancer cells through mitophagy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-1021-9
Abstract: BackgroundAbiraterone and MDV3100 are two effective anticancer agents for prostate cancer, however, the mechanism of their downstream action remains undefined.MethodsA dual fluorescent biosensor plasmid was transfected in LNCaP cells to measure mitophagy. The DNA of… read more here.
Keywords: lncap cells; abiraterone mdv3100; cancer; proliferation ... See more keywords
Calcium signaling in prostate cancer cells of increasing malignancy
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecular Concepts"
DOI: 10.1515/bmc-2022-0012
Abstract: Abstract Calcium signaling controls a large variety of cell functions, including proliferation and apoptosis, and plays a major role in neoplastic transformation. Prostate cancer (PCa) is one of the most common malignancies in men. The… read more here.
Keywords: cancer; lncap cells; calcium signaling; prostate cancer ... See more keywords
Acute hypoxia induces apoptosis in serum-deprived prostate cancer LNCaP cells
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/16775
Abstract: Background: Human prostate cancer LNCaP cells can develop an androgen-sensitive prostate cancer animal model that closely mimic clinical disease. However, implantation of LNCaP cells yields a low take rate when subcutaneously xenografted in immunodeficient mice.… read more here.
Keywords: lncap cells; acute hypoxia; lncap; prostate cancer ... See more keywords
URG11 promotes proliferation and induced apoptosis of LNCaP cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2019.4121
Abstract: von Willebrand factor C and EGF domain-containing protein (URG11), a cell growth regulator, is involved in the progression of a variety of types of cancer, including prostate cancer (Pca). However, the functions of the URG11… read more here.
Keywords: apoptosis; lncap cells; viability migration; pca ... See more keywords
The Differential Antitumor Activity of 5-Aza-2'-deoxycytidine in Prostate Cancer DU145, 22RV1, and LNCaP Cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer"
DOI: 10.7150/jca.56709
Abstract: DNA methylation is a DNA methyltransferase-mediated epigenetic modification affecting gene expression. This process is involved in the initiation and development of malignant disease. 5‐Aza‐2′‐deoxycytidine (5‐Aza), a classic DNA methyltransferase inhibitor, possesses antitumor proliferation activity. However,… read more here.
Keywords: lncap cells; 22rv1 lncap; expression; prostate cancer ... See more keywords