Construction of a disease‐specific lncRNA‐miRNA‐mRNA regulatory network reveals potential regulatory axes and prognostic biomarkers for hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3526
Abstract: Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with a high incidence and poor prognosis. Exploration of the underlying mechanisms and effective prognostic indicators is conducive to clinical management and optimization of treatment. The RNA‐seq and… read more here.
Keywords: hcc; network; regulatory axes; lncrna mirna ... See more keywords
Application of lncRNA–miRNA–mRNA ceRNA network analysis in the treatment of androgenic alopecia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24791
Abstract: Long noncoding RNAs (lncRNAs) can be used as competitive endogenous RNAs (ceRNAs) to bind to microRNAs (miRNAs) to regulate gene expression. Previous studies have demonstrated that ceRNAs play an important role in the development of… read more here.
Keywords: androgenic alopecia; mirna mrna; cerna network; lncrna mirna ... See more keywords
Predicting lncRNA-miRNA interactions based on interactome network and graphlet interaction.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.02.002
Abstract: In the development and treatment of many human diseases, the regulatory roles between lncRNAs and miRNAs are important, but much remains unknown about them; moreover, experimental methods for analyzing them are expensive and time-consuming. In… read more here.
Keywords: interactome network; lncrna mirna; graphlet interaction; interaction ... See more keywords
Transcriptome sequencing and lncRNA-miRNA-mRNA network construction in cardiac fibrosis and heart failure
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2045839
Abstract: ABSTRACT Cardiac fibrosis (CF) and heart failure (HF) are common heart diseases, and severe CF can lead to HF. In this study, we tried to find their common potential molecular markers, which may help the… read more here.
Keywords: network; heart failure; cardiac fibrosis; lncrna mirna ... See more keywords
Predicting miRNA-disease associations based on lncRNA-miRNA interactions and graph convolution networks
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac495
Abstract: Increasing studies have proved that microRNAs (miRNAs) are critical biomarkers in the development of human complex diseases. Identifying disease-related miRNAs is beneficial to disease prevention, diagnosis and remedy. Based on the assumption that similar miRNAs… read more here.
Keywords: mirna interactions; disease; disease associations; lncrna mirna ... See more keywords
ISLMI:Predicting lncRNA-miRNA Interactions Based on Information Injection and Second-Order Graph Convolution Network.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2022.3215151
Abstract: Studies have shown that IncRNA-miRNA interactions can affect cellular expression at the level of gene molecules through a variety of regulatory mechanisms and have important effects on the biological activities of living organisms. Several biomolecular… read more here.
Keywords: information; network; mirna interactions; lncrna mirna ... See more keywords
Identification of potential lncRNA‐miRNA‐mRNA regulatory network contributing to aldosterone‐producing adenoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17586
Abstract: Aldosterone‐producing adenoma (APA) is a common cause of secondary hypertension. This study aimed to explore the lncRNA‐miRNA‐mRNA competitive endogenous RNA (ceRNA) network to uncover molecular mechanism underlying APA. The mRNA and lncRNA expression data of… read more here.
Keywords: network; mirna mrna; aldosterone producing; lncrna mirna ... See more keywords
Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/3859582
Abstract: The regulation of transcriptome expression level is a complex process involving multiple-level interactions among molecules such as protein coding RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA), which are essential for the transcriptome stability… read more here.
Keywords: network; mrna lncrna; lncrna mirna; endometrial carcinoma ... See more keywords
The ceRNA Crosstalk between mRNAs and lncRNAs in Diabetes Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/4283534
Abstract: Competitive endogenous RNA regulation suggests an intricate network of all transcriptional RNAs that have the function of repressing miRNA function and regulating mRNA expression. Today, the specific ceRNA regulatory mechanisms of lncRNA–miRNA–mRNA in patients who… read more here.
Keywords: network; mirna mrna; cerna; myocardial infarction ... See more keywords
Prediction of Functional Genes in Primary Varicose Great Saphenous Veins Using the lncRNA-miRNA-mRNA Network
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/4722483
Abstract: Background Long noncoding RNAs (lncRNAs) have been widely suggested to bind with the microRNA (miRNA) sites and play roles of competing endogenous RNAs (ceRNAs), which can thus affect and regulate target gene and mRNA expression.… read more here.
Keywords: saphenous veins; network; mirna mrna; great saphenous ... See more keywords
Integrated analysis of lncRNA, miRNA and mRNA reveals novel insights into the fertility regulation of large white sows
Sign Up to like & getrecommendations! Published in 2020 at "BMC Genomics"
DOI: 10.1186/s12864-020-07055-2
Abstract: Background Improving sow fertility is extremely important as it can lead to increased reproductive efficiency and thus profitability for swine producers. There are considerable differences in fertility rates among individual animals, but the underlying molecular… read more here.
Keywords: analysis; lncrna mirna; large white; mirna mrna ... See more keywords