WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28990-6
Abstract: N6-methyladenosine (m6A) is the most prevalent RNA modification at the posttranscriptional level and involved in various diseases and cellular processes. However, the underlying mechanism of m6A regulation in intervertebral disc degeneration (IVDD) remains elusive. Here,… read more here.
Keywords: m6a modification; disc degeneration; intervertebral disc; lncrna norad ... See more keywords
LncRNA NORAD regulates the mechanism of the miR-532-3p/Nectin-4 axis in pancreatic cancer cell proliferation and angiogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Toxicology Research"
DOI: 10.1093/toxres/tfad026
Abstract: Pancreatic cancer (PC) is one of the deadliest cancers worldwide, and cell proliferation and angiogenesis play an important role in its occurrence and development. High levels of lncRNANORAD have been detected in many tumors, including… read more here.
Keywords: angiogenesis; lncrna norad; proliferation angiogenesis; mir 532 ... See more keywords
High long non-coding RNA NORAD expression predicts poor prognosis and promotes breast cancer progression by regulating TGF-β pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-0781-6
Abstract: AbstractBackgroundTo investigate the expression and significance of long noncoding RNA NORAD (lncRNA-NORAD) in breast cancer.MethodsQ-PCR was adopted to detect the mRNA expression of lncRNA-NORAD in breast cancer and adjacent tissues, survival analysis to compare the… read more here.
Keywords: lncrna norad; breast cancer; rna norad; expression ... See more keywords
Long non-coding RNA NORAD promotes pancreatic cancer stem cell proliferation and self-renewal by blocking microRNA-202-5p-mediated ANP32E inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-021-03052-5
Abstract: Background Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long noncoding RNAs (lncRNAs) has… read more here.
Keywords: cancer stem; lncrna norad; self renewal; mir 202 ... See more keywords