Optimizing Lipid Nanoparticles for Delivery in Primates.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211420
Abstract: Lipid nanoparticles (LNPs) are clinically proven to successfully deliver both small interfering RNA (siRNA) therapeutics and larger mRNA payloads for prophylactic vaccine applications. Non-human primates (NHPs) are generally considered to be the most predictive of… read more here.
Keywords: nanoparticles delivery; potency; optimizing lipid; delivery primates ... See more keywords
Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303261
Abstract: Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to the success of COVID-19 mRNA vaccines (Comirnaty and Spikevax). To meet the therapeutic purpose, it is required that… read more here.
Keywords: nanoparticle lnp; lnp; therapy; lipid nanoparticle ... See more keywords
Efficient Delivery of Globotriaosylceramide Synthase siRNA using Polyhistidine-Incorporated Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200423
Abstract: In this study, a novel polyhistidine (pHis)-incorporated lipid nanoparticle (pHis/LNP) was developed for the delivery of therapeutic globotriaosylceramide (Gb3) synthase siRNAs using a microfluidic device with pHis as a biocompatible method of endosome escape. To… read more here.
Keywords: synthase; gb3 synthase; phis lnp; lnp ... See more keywords
The Significance of Histologically “Large Normal” Parathyroid Glands in Primary Hyperparathyroidism
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DOI: 10.1007/s00268-019-05302-6
Abstract: Introduction We investigated outcomes in a cohort of patients with a biochemical diagnosis of primary hyperparathyroidism (pHPT) undergoing surgery for asymptomatic disease or target organ damage, where a focussed or four-gland operation was undertaken and… read more here.
Keywords: large normal; primary hyperparathyroidism; lnp; phpt ... See more keywords
Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters
Sign Up to like & getrecommendations! Published in 2022 at "Cell Research"
DOI: 10.1038/s41422-022-00630-0
Abstract: Monoclonal antibodies represent important weapons in our arsenal to against the COVID-19 pandemic. However, this potential is severely limited by the time-consuming process of developing effective antibodies and the relative high cost of manufacturing. Herein,… read more here.
Keywords: sars cov; protection sars; antibody; lnp ... See more keywords
Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-123709
Abstract: Background: NUP98-NSD1 positive AML is a poor prognostic subgroup within pediatric and adult AML (Thol et al., 2013). However, targeted therapeutics for these AML patients are not available to date. As a result of the… read more here.
Keywords: nup98 nsd1; treatment; lnp; fusion ... See more keywords
Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010830
Abstract: Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and… read more here.
Keywords: exposure mrna; lnp; pre exposure; adaptive immune ... See more keywords