Beyond the Endosomal Bottleneck: Understanding the Efficiency of mRNA/LNP Delivery
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202404510
Abstract: The development of lipid nanoparticles (LNP) holds great promise for vaccine and therapeutic applications. However, ineffective transport of nucleic acid cargo from endosomes to the cytosol, termed “endosomal escape,” has remained a bottleneck to achieving… read more here.
Keywords: mrna lnp; efficiency; delivery; lnp ... See more keywords
Optimizing Lipid Nanoparticles for Delivery in Primates.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211420
Abstract: Lipid nanoparticles (LNPs) are clinically proven to successfully deliver both small interfering RNA (siRNA) therapeutics and larger mRNA payloads for prophylactic vaccine applications. Non-human primates (NHPs) are generally considered to be the most predictive of… read more here.
Keywords: nanoparticles delivery; potency; optimizing lipid; delivery primates ... See more keywords
Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303261
Abstract: Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to the success of COVID-19 mRNA vaccines (Comirnaty and Spikevax). To meet the therapeutic purpose, it is required that… read more here.
Keywords: nanoparticle lnp; lnp; therapy; lipid nanoparticle ... See more keywords
Efficient Delivery of Globotriaosylceramide Synthase siRNA using Polyhistidine-Incorporated Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200423
Abstract: In this study, a novel polyhistidine (pHis)-incorporated lipid nanoparticle (pHis/LNP) was developed for the delivery of therapeutic globotriaosylceramide (Gb3) synthase siRNAs using a microfluidic device with pHis as a biocompatible method of endosome escape. To… read more here.
Keywords: synthase; gb3 synthase; phis lnp; lnp ... See more keywords
The Significance of Histologically “Large Normal” Parathyroid Glands in Primary Hyperparathyroidism
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Surgery"
DOI: 10.1007/s00268-019-05302-6
Abstract: Introduction We investigated outcomes in a cohort of patients with a biochemical diagnosis of primary hyperparathyroidism (pHPT) undergoing surgery for asymptomatic disease or target organ damage, where a focussed or four-gland operation was undertaken and… read more here.
Keywords: large normal; primary hyperparathyroidism; lnp; phpt ... See more keywords
High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c01171
Abstract: Immune modulation through the intracellular delivery of nucleoside-modified mRNA to immune cells is an attractive approach for in vivo immunoengineering, with applications in infectious disease, cancer immunotherapy, and beyond. Lipid nanoparticles (LNPs) have come to… read more here.
Keywords: high throughput; throughput vivo; delivery; administration ... See more keywords
Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters
Sign Up to like & getrecommendations! Published in 2022 at "Cell Research"
DOI: 10.1038/s41422-022-00630-0
Abstract: Monoclonal antibodies represent important weapons in our arsenal to against the COVID-19 pandemic. However, this potential is severely limited by the time-consuming process of developing effective antibodies and the relative high cost of manufacturing. Herein,… read more here.
Keywords: sars cov; protection sars; antibody; lnp ... See more keywords
Enhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50087-5
Abstract: Enhancing influenza vaccine cross-protection is imperative to alleviate the significant public health burden of influenza. Heterologous sequential immunization may synergize diverse vaccine formulations and routes to improve vaccine potency and breadth. Here we investigate the… read more here.
Keywords: protection; immunization; cross protection; nanoparticle ... See more keywords
Designing lipid nanoparticles using a transformer-based neural network
Sign Up to like & getrecommendations! Published in 2025 at "Nature Nanotechnology"
DOI: 10.1038/s41565-025-01975-4
Abstract: The RNA medicine revolution has been spurred by lipid nanoparticles (LNPs). The effectiveness of an LNP is determined by its lipid components and their ratios; however, experimental optimization is laborious and does not explore the… read more here.
Keywords: transformer based; based neural; lipid nanoparticles; neural network ... See more keywords
Abstract 6119: Efficient generation of active CAR-T cells from healthy donors and lymphoma patients
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6119
Abstract: CAR T-cells have set a new standard of clinical activity in patients with hematologic malignancies but there are several barriers to broader patient access. Currently, the genetic modification of patients' T cells to produce CAR-T… read more here.
Keywords: lymphoma patients; active car; car expression; car ... See more keywords
Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-123709
Abstract: Background: NUP98-NSD1 positive AML is a poor prognostic subgroup within pediatric and adult AML (Thol et al., 2013). However, targeted therapeutics for these AML patients are not available to date. As a result of the… read more here.
Keywords: nup98 nsd1; treatment; lnp; fusion ... See more keywords