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   Articles with "lnps" as a keyword



Design of PD‐L1‐Targeted Lipid Nanoparticles to Turn on PTEN for Efficient Cancer Therapy

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202309917

Abstract: Lipid nanoparticles (LNPs) exhibit remarkable mRNA delivery efficiency, yet their majority accumulate in the liver or spleen after injection. Tissue‐specific mRNA delivery can be achieved through modulating LNP properties, such as tuning PEGylation or varying… read more here.

Keywords: cancer; cancer therapy; lipid nanoparticles; lnps ... See more keywords

In Vivo Endothelial Cell Gene Silencing by siRNA-LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting.

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recommendations! Published in 2024 at "Small"

DOI: 10.1002/smll.202400643

Abstract: Although small-interfering RNAs (siRNAs) are specific silencers for numerous disease-related genes, their clinical applications still require safe and effective means of delivery into target cells. Highly efficient lipid nanoparticles (LNPs) are developed for siRNA delivery,… read more here.

Keywords: gene silencing; lipoamino; sirna lnps; endothelial cell ... See more keywords

Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery.

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recommendations! Published in 2018 at "Acta biomaterialia"

DOI: 10.1016/j.actbio.2018.09.047

Abstract: Lipid-based nanoparticles (LNPs) have been developed to address the transport and uptake barriers to enhance the delivery efficiency of plasmid DNA therapeutics. In these systems, plasmid DNA can be encapsulated through condensation by a cationic… read more here.

Keywords: dna; nanoparticle; turbulent mixing; size ... See more keywords

Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.03.073

Abstract: Protein-protein (e.g., antibody-antigen) interactions comprise multiple weak interactions. We have previously reported that lipid nanoparticles (LNPs) bind to and neutralize target toxic peptides after multifunctionalization of the LNP surface (MF-LNPs) with amino acid derivatives that… read more here.

Keywords: target toxin; target; lnps; neutralization ... See more keywords

Enhancing the Radical Scavenging Activity and UV Resistance of Lignin Nanoparticles via Surface Mannich Amination toward a Biobased Antioxidant.

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recommendations! Published in 2021 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.1c00387

Abstract: In recent years, lignin specific activities, such as antioxidation and antibacterial and anti-ultraviolet performance, have drawn more and more attention. Nevertheless, the insufficient radical scavenging (antioxidation) activity has become one of the main drawbacks that… read more here.

Keywords: lignin nanoparticles; radical scavenging; lnps; biobased antioxidant ... See more keywords

Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.

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recommendations! Published in 2022 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.2c00033

Abstract: Ionizable cationic lipids are essential for efficient in vivo delivery of RNA by lipid nanoparticles (LNPs). DLin-MC3-DMA (MC3), ALC-0315, and SM-102 are the only ionizable cationic lipids currently clinically approved for RNA therapies. ALC-0315 and… read more here.

Keywords: mc3; alc 0315; ionizable cationic; dlin mc3 ... See more keywords

Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model.

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recommendations! Published in 2022 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.2c00442

Abstract: Within the field of lipid nanoparticles (LNPs) for RNA delivery, the focus has been mainly placed on organ level delivery, which can mask cellular level effects consequential to therapeutic applications. Here, we studied a pair… read more here.

Keywords: chemistry; rna delivery; lnps; therapeutic outcomes ... See more keywords

Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA.

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recommendations! Published in 2023 at "ACS nano"

DOI: 10.1021/acsnano.2c10501

Abstract: Based on the clinical success of an in vitro transcribed mRNA (IVT-mRNA) that is encapsulated in lipid nanoparticles (mRNA-LNPs), there is a growing demand by researchers to test whether their own biological findings might be… read more here.

Keywords: ivt mrna; formulation; ready use; mrna lnps ... See more keywords

Biodegradable Lipid-Modified Poly(Guanidine Thioctic Acid)s: A Fortifier of Lipid Nanoparticles to Promote the Efficacy and Safety of mRNA Cancer Vaccines.

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.3c14010

Abstract: Lipid nanoparticles (LNPs)-based messenger RNA (mRNA) therapeutics have emerged with promising potentials in the fields of infectious diseases, cancer vaccines, and protein replacement therapies; however, their therapeutic efficacy and safety can still be promoted by… read more here.

Keywords: mrna; efficacy; cancer vaccines; lipid nanoparticles ... See more keywords

A simple and effective approach to fabricate lignin nanoparticles with tunable sizes based on lignin fractionation

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recommendations! Published in 2020 at "Green Chemistry"

DOI: 10.1039/d0gc00377h

Abstract: In recent years, an increasing number of studies have shown that lignin nanoparticles (LNPs) are a new kind of green and sustainable material with potential applications in many areas. With the development of nanotechnology, the… read more here.

Keywords: simple effective; fractionation; tunable sizes; lignin nanoparticles ... See more keywords

RNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae648

Abstract: Abstract Lipid nanoparticles (LNPs) have been demonstrated to hold great promise for the clinical advancement of RNA therapeutics. Continued exploration of LNPs for application in new disease areas requires identification and optimization of leads in… read more here.

Keywords: delivery; peptide barcodes; rna; vivo screening ... See more keywords