Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.09.047
Abstract: Lipid-based nanoparticles (LNPs) have been developed to address the transport and uptake barriers to enhance the delivery efficiency of plasmid DNA therapeutics. In these systems, plasmid DNA can be encapsulated through condensation by a cationic… read more here.
Keywords: dna; nanoparticle; turbulent mixing; size ... See more keywords
Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.03.073
Abstract: Protein-protein (e.g., antibody-antigen) interactions comprise multiple weak interactions. We have previously reported that lipid nanoparticles (LNPs) bind to and neutralize target toxic peptides after multifunctionalization of the LNP surface (MF-LNPs) with amino acid derivatives that… read more here.
Keywords: target toxin; target; lnps; neutralization ... See more keywords
Enhancing the Radical Scavenging Activity and UV Resistance of Lignin Nanoparticles via Surface Mannich Amination toward a Biobased Antioxidant.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c00387
Abstract: In recent years, lignin specific activities, such as antioxidation and antibacterial and anti-ultraviolet performance, have drawn more and more attention. Nevertheless, the insufficient radical scavenging (antioxidation) activity has become one of the main drawbacks that… read more here.
Keywords: lignin nanoparticles; radical scavenging; lnps; biobased antioxidant ... See more keywords
Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00033
Abstract: Ionizable cationic lipids are essential for efficient in vivo delivery of RNA by lipid nanoparticles (LNPs). DLin-MC3-DMA (MC3), ALC-0315, and SM-102 are the only ionizable cationic lipids currently clinically approved for RNA therapies. ALC-0315 and… read more here.
Keywords: mc3; alc 0315; ionizable cationic; dlin mc3 ... See more keywords
Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00442
Abstract: Within the field of lipid nanoparticles (LNPs) for RNA delivery, the focus has been mainly placed on organ level delivery, which can mask cellular level effects consequential to therapeutic applications. Here, we studied a pair… read more here.
Keywords: chemistry; rna delivery; lnps; therapeutic outcomes ... See more keywords
Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c10501
Abstract: Based on the clinical success of an in vitro transcribed mRNA (IVT-mRNA) that is encapsulated in lipid nanoparticles (mRNA-LNPs), there is a growing demand by researchers to test whether their own biological findings might be… read more here.
Keywords: ivt mrna; formulation; ready use; mrna lnps ... See more keywords
A simple and effective approach to fabricate lignin nanoparticles with tunable sizes based on lignin fractionation
Sign Up to like & getrecommendations! Published in 2020 at "Green Chemistry"
DOI: 10.1039/d0gc00377h
Abstract: In recent years, an increasing number of studies have shown that lignin nanoparticles (LNPs) are a new kind of green and sustainable material with potential applications in many areas. With the development of nanotechnology, the… read more here.
Keywords: simple effective; fractionation; tunable sizes; lignin nanoparticles ... See more keywords
Intracellular trafficking kinetics of nucleic acid escape from lipid nanoparticles via fluorescence imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230403094238
Abstract: INTRODUCTION Lipid nanoparticles (LNPs) are one of the most clinically advanced candidates for delivering nucleic acids to target cell populations, such as hepatocytes. Once LNPs are endocytosed, they must release their nucleic acid cargo into… read more here.
Keywords: formulation; intracellular trafficking; microscopy; lnps ... See more keywords
Improved Light and In Vitro Digestive Stability of Lutein-Loaded Nanoparticles Based on Soy Protein Hydrolysates via Pepsin
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11223635
Abstract: In order to improve the water solubility and stability of lutein, soy protein isolates (SPI) and their hydrolysates via pepsin (PSPI) and alcalase (ASPI) were used as nanocarriers for lutein to fabricate the lutein-loaded nanoparticles… read more here.
Keywords: stability lutein; digestive stability; lutein; lnps ... See more keywords
Delivery of DNA into Human Cells by Functionalized Lignin Nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15010303
Abstract: Lignin is an aromatic plant cell wall polymer that is generated in large quantities as a low-value by-product by the pulp and paper industry and by biorefineries that produce renewable fuels and chemicals from plant… read more here.
Keywords: dna; lnps; cells functionalized; lignin ... See more keywords
Multicomponent Lipid Nanoparticles for RNA Transfection
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041289
Abstract: Despite the wide variety of available cationic lipid platforms for the delivery of nucleic acids into cells, the optimization of their composition has not lost its relevance. The purpose of this work was to develop… read more here.
Keywords: rna transfection; lnps; nanoparticles rna; multicomponent lipid ... See more keywords