Surface-modified particles loaded with CaMKII inhibitor protect cardiac cells against mitochondrial injury.
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DOI: 10.1016/j.ijpharm.2017.01.061
Abstract: An excess of calcium (Ca2+) influx into mitochondria during mitochondrial re-energization is one of the causes of myocardial cell death during ischemic/reperfusion injury. This overload of Ca2+ triggers the mitochondrial permeability transition pore (mPTP) opening… read more here.
Keywords: camkii inhibitor; injury; tpp cip; loaded camkii ... See more keywords