Transdermal delivery of curcumin-loaded supramolecular hydrogels for dermatitis treatment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-018-6215-5
Abstract: AbstractCurcumin (CUR) is a hydrophobic polyphenol with anti-inflammatory activity. However, its low water-solubility and poor skin permeation limited its application in the treatment of dermititis. CUR-loaded micelles were prepared using thin membrane hydration method with… read more here.
Keywords: supramolecular hydrogels; treatment; loaded supramolecular; cur ... See more keywords
Shear-responsive injectable supramolecular hydrogel releasing doxorubicin loaded micelles with pH-sensitivity for local tumor chemotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.07.063
Abstract: In this study, glycol chitosan-Pluronic F127 conjugate (GC-PF127), produced by an amidation reaction between terminal-carboxylated PF127 and glycol chitosan (GC), was used to prepare doxorubicin (DOX)-loaded micelles. The DOX/GC-PF127 micelles produced at optimal conditions had… read more here.
Keywords: hydrogel; shear responsive; dox pf127; loaded micelles ... See more keywords
Methotrexate‐loaded biodegradable polymeric micelles for lymphoma therapy
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.12.025
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Drug resistance and recurrence are the main clinical challenges in chemotherapy of lymphoma. Methotrexate (MTX), especially high dose MTX (HD MTX), is extensively used to treat some aggressive… read more here.
Keywords: mtx loaded; high dose; drug; mpeg pcl ... See more keywords
Anti-breast cancer activity of novel compounds loaded in polymeric mixed micelles: Characterization and in vitro studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102815
Abstract: Abstract We designed and synthesized three new compounds against breast cancer. The first, N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), aims to target histone deacetylase. The other two compounds, (3aS, 4R, 9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic (E)-N,N′-diisopropylcarbamimidic anhydride (ISOUREA) and (3aS, 4R, 9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-5-(tert-butoxycarbonyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid… read more here.
Keywords: mixed polymeric; microscopy; breast cancer; drug ... See more keywords
Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00558
Abstract: Ulcerative colitis is a multifactorial disease of the gastrointestinal tract which is caused due to chronic inflammation in the colon; it usually starts from the lower end of the colon and may spread to other… read more here.
Keywords: loaded micelles; microscopy; bud loaded; colitis ... See more keywords
Doxorubicin-loaded micelles with high drug-loading capacity and stability based on zwitterionic oligopeptides
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj02785e
Abstract: To simplify the preparation process and increase the drug-loading capacity of antitumor nanodrugs, doxorubicin-loaded micelles based on zwitterionic oligopeptides were fabricated through two step reactions in mild conditions. Zwitterionic oligopeptides Glu–Lys–Cys–Glu–Lys (EKCEK) were reacted with… read more here.
Keywords: drug loading; drug; loading capacity; doxorubicin loaded ... See more keywords
Effect of tertiary amino groups in the hydrophobic segment of an amphiphilic block copolymer on zinc phthalocyanine encapsulation and photodynamic activity
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02224a
Abstract: Polymer micelles are promising nanocarriers for hydrophobic photosensitizers of photodynamic therapy (PDT). Poly(styrene-co-(2-(N,N-dimethylamino)ethyl acrylate))-block-poly(polyethylene glycol monomethyl ether acrylate) (P(St-co-DMAEA)-b-PPEGA; 1) was prepared via reversible addition and fragmentation chain transfer (RAFT) polymerization as a carrier for… read more here.
Keywords: loaded micelles; znpc loaded; znpc; zinc phthalocyanine ... See more keywords
Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s124843
Abstract: The combination of chemotherapy drugs attracts more attention in clinical cancer trials. However, the poor water solubility of chemotherapeutic drugs restricts their anticancer application. In order to improve antitumor efficiency and reduce side effects of… read more here.
Keywords: breast cancer; loaded micelles; cancer; cancer therapy ... See more keywords
Novel pH-Sensitive Urushiol-Loaded Polymeric Micelles for Enhanced Anticancer Activity
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s250564
Abstract: Purpose The aim of this study was to develop a means of improving the bioavailability and anticancer activity of urushiol by developing an urushiol-loaded novel tumor-targeted micelle delivery system based on amphiphilic block copolymer poly(ethylene… read more here.
Keywords: loaded micelles; anticancer activity; release; urushiol loaded ... See more keywords
Differential Cytotoxicity of Curcumin-Loaded Micelles on Human Tumor and Stromal Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012362
Abstract: Although curcumin in the form of nanoparticles has been demonstrated as a potential anti-tumor compound, the impact of curcumin and nanocurcumin in vitro on normal cells and in vivo in animal models is largely unknown.… read more here.
Keywords: loaded micelles; cytotoxicity; curcumin; curcumin loaded ... See more keywords
Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26154481
Abstract: Prolonging in vivo circulation has proved to be an efficient route for enhancing the therapeutic effect of rapidly metabolized drugs. In this study, we aimed to construct a nanocrystal-loaded micelles delivery system to enhance the… read more here.
Keywords: nanocrystal loaded; vivo circulation; doc mpeg; circulation ... See more keywords