Preparation and characterization of citral-loaded solid lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Food chemistry"
DOI: 10.1016/j.foodchem.2017.11.091
Abstract: Citral-loaded solid lipid nanoparticles (citral-SLNs) were prepared via a high-pressure homogenization method, using glyceryl monostearate (GMS) as the solid lipid and a mixture of Tween 80 (T-80) and Span 80 (S-80) at a weight ratio… read more here.
Keywords: citral loaded; citral slns; lipid nanoparticles; preparation characterization ... See more keywords
Development of ibuprofen-loaded solid lipid nanoparticle-based hydrogels for enhanced in vitro dermal permeation and in vivo topical anti-inflammatory activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101758
Abstract: Abstract In this study, hydrogels containing ibuprofen-loaded solid lipid nanoparticles (IBU-loaded SLNs) were developed to enhance the skin penetration of ibuprofen and for the local treatment of inflammation in experimental rats. IBU-loaded SLNs were prepared… read more here.
Keywords: based hydrogels; ibu loaded; ibuprofen loaded; loaded solid ... See more keywords
Diosmin-loaded solid nanoparticles as nano-antioxidant therapy for management of hepatocellular carcinoma: QbD-based optimization, in vitro and in vivo evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.102213
Abstract: Abstract The present work focuses on the development and evaluation of the diosmin-loaded solid lipid nanoparticles (SLNs) with the goal of improving its therapeutic efficacy in hepatic carcinoma (HCC) treatment. HCC was induced by administration… read more here.
Keywords: carcinoma; diosmin loaded; diosmin; evaluation ... See more keywords
Preparation, characterization and in vivo pharmacokinetic evaluation of curcuminoids-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102352
Abstract: Abstract Curcuminoids are considered as one of the most promising phytochemicals with numerous pharmacological effects and therapeutic potentials. Nevertheless, their inappropriate pharmacokinetic properties (i.e., poor bioavailability) have made pharmaceutical industries face many challenges in developing… read more here.
Keywords: loaded solid; nanostructured lipid; curcuminoids loaded; lipid nanoparticles ... See more keywords
Improvement of memory deficits in the rat model of Alzheimer's disease by erythropoietin-loaded solid lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.107082
Abstract: Erythropoietin (EPO), a hematopoietic factor, is one of the promising neuroprotective candidates in neurodegenerative disorders such as Alzheimer's disease (AD). Due to the high molecular weight, hydrophilicity and rapid clearance from circulation, EPO could not… read more here.
Keywords: alzheimer disease; epo; sln; loaded solid ... See more keywords
Development of Pomegranate Extract-Loaded Solid Lipid Nanoparticles: Quality by Design Approach to Screen the Variables Affecting the Quality Attributes and Characterization
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02618
Abstract: The aim of this work was to study the influence of process variables on the quality attributes of pomegranate extract loaded solid lipid nanoparticles (PE-SLNs) using Plackett–Burman design. PE-SLN formulations were prepared by hot homogenization… read more here.
Keywords: quality; quality attributes; pomegranate extract; extract loaded ... See more keywords
VitD3-loaded solid lipid nanoparticles: stability, cytotoxicity and cytokine levels
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2017.1345995
Abstract: Abstract Vitamin D3 (VitD3) has several beneficial effects on many metabolic pathways such as immunity system, bone development. The aim of the study, encapsulation of VitD3 with solid lipids, determine encapsulation efficiency and biocompatibility of… read more here.
Keywords: vitd3; lipid nanoparticles; vitd3 loaded; stability ... See more keywords
Development of levosulpiride-loaded solid lipid nanoparticles and their in vitro and in vivo comparison with commercial product
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2020.1713242
Abstract: Abstract The aim of this study was to develop levosulpiride-loaded solid lipid nanoparticles (SLNs) with enhanced solubilisation and bioavailability. The levosulpiride loaded-SLNs were composed of levosulpiride, stearic acid, and tween 80 in their respective weight… read more here.
Keywords: commercial product; product; lipid nanoparticles; loaded solid ... See more keywords
Amphotericin B loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carrier (NLCs): physicochemical and solid-solution state characterizations
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2019.1569023
Abstract: Abstract Amphotericin B (AmB) is one of the most effective systemic antifungal agents, but its use is circumscribed by the dose-limiting toxicity of the conventional micellar dispersion formulation, Fungizone®. Significantly lesser toxicity is obtained when… read more here.
Keywords: nanoparticles slns; slns nanostructured; nanostructured lipid; lipid nanoparticles ... See more keywords
Pharmacokinetic, toxicokinetic, and bioavailability studies of epigallocatechin-3-gallate loaded solid lipid nanoparticle in rat model
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2019.1634091
Abstract: Abstract Epigallocatechin-3-gallate (EGCG), derived from green tea, is an active phytochemical against many types of cancer, cardiovascular, neurological and inflammatory diseases. However, its pharmaceutical activity is limited due to low bioavailability and chemical instability. To… read more here.
Keywords: bioavailability; epigallocatechin gallate; model; sln egcg ... See more keywords
Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity: Role of inducible nitric oxide synthase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Liposome Research"
DOI: 10.1080/08982104.2022.2032737
Abstract: Abstract Curcumin (Cur) is a natural compound that exhibited therapeutic effects against various liver injuries however Cur showed poor water solubility and bioavailability. This study aimed to design Cur-loaded solid lipid nanoparticles (SLNs) and to… read more here.
Keywords: solid lipid; loaded solid; cur; curcumin ... See more keywords