Variability of voriconazole concentrations in patients with hematopoietic stem cell transplantation and hematological malignancies: influence of loading dose, procalcitonin, and pregnane X receptor polymorphisms
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02831-1
Abstract: Aims Voriconazole (VCZ) displays highly variable pharmacokinetics affecting treatment efficacy and safety. We aimed to identify the factors affecting VCZ steady-state trough concentration (Cssmin) to provide evidence for optimizing VCZ treatment regimens. Methods A total… read more here.
Keywords: cssmin; hematopoietic stem; pxr; vcz ... See more keywords
Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02840-0
Abstract: To assess the efficacy of loading dose on micafungin by simulating different dosage regimens. A published study of micafungin in ICU patients was employed to simulate nine different dosage regimens which were sorted out three… read more here.
Keywords: auc mic; candida spp; icu patients; dosage ... See more keywords
Use of the VerifyNow point of care assay to assess the pharmacodynamic effects of loading and maintenance dose regimens of prasugrel and ticagrelor
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-021-02386-7
Abstract: Prasugrel and ticagrelor are potent oral platelet P2Y12 inhibitors and are recommended over clopidogrel in patients with acute coronary syndrome (ACS). Oral platelet P2Y12 inhibitors are characterized by varying degrees of pharmacodynamic response profiles as… read more here.
Keywords: use; maintenance dose; ticagrelor; prasugrel ticagrelor ... See more keywords
Evaluation of the Pharmacokinetics and Pharmacodynamics of Prasugrel in Japanese Elderly Subjects
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DOI: 10.1007/s40261-017-0525-0
Abstract: Background and ObjectiveAn increased incidence in bleeding events has been reported in Western elderly patients receiving prasugrel. Therefore, doses in Japanese elderly subjects need to be carefully determined. We assessed the pharmacokinetic and pharmacodynamic effects… read more here.
Keywords: plasma concentration; elderly subjects; maintenance dose; japanese elderly ... See more keywords
Reduction of No Reflow with a Loading Dose of Atorvastatin before Primary Angioplasty in Patients with Acute ST Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2018.10.006
Abstract: BACKGROUND No reflow defined as an altered myocardial reperfusion and failure at microvascular level is a frequent complication in acute myocardial infarction that attenuates beneficial effect of reperfusion therapy leading to poor outcomes. There is… read more here.
Keywords: dose atorvastatin; atorvastatin primary; myocardial infarction; acute myocardial ... See more keywords
Electrical activity of the diaphragm following a loading dose of caffeine citrate in ventilated preterm infants
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0619-x
Abstract: Background Administration of caffeine citrate can facilitate extubation. Our aim was to determine whether a loading dose of caffeine citrate given to ventilated, preterm infants affected the diaphragm electrical activity. Methods Infants read more here.
Keywords: electrical activity; dose caffeine; citrate; caffeine citrate ... See more keywords
Efficacy of secukinumab without the initial weekly loading dose in patients with chronic plaque psoriasis
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18015
Abstract: Secukinumab is administered at the labelled dose of 300 mg at weeks 0, 1, 2, 3, 4 (loading dose) and every 4 weeks thereafter. read more here.
Keywords: efficacy secukinumab; initial weekly; without initial; secukinumab ... See more keywords
Optimized Loading Dose Strategies for Bedaquiline When Restarting Interrupted Drug-Resistant Tuberculosis Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01749-21
Abstract: Interruption of treatment is common in drug-resistant tuberculosis patients. Bedaquiline has a long terminal half-life; therefore, restarting after an interruption without a loading dose could increase the risk of suboptimal treatment outcome and resistance development.… read more here.
Keywords: loading dose; strategies bedaquiline; resistant tuberculosis; drug resistant ... See more keywords
Are the loading dose treatment groups superior to the 150 mg without loading dose group in the secukinumab FUTURE 5 study
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-213770
Abstract: I read with great interest the article by Mease et al 1 because equivalence in efficacy with lesser secukinumab total doses could be less expensive to payers and more safe and comfortable to patients. However, I am… read more here.
Keywords: loading dose; 150 without; treatment groups; superior 150 ... See more keywords
Chewing versus Swallowing Ticagrelor to Accelerate Platelet Inhibition in Acute Coronary Syndrome - the CHEERS study. For The PLATIS (Platelets and Thrombosis in Sheba) Study Group.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th16-09-0728
Abstract: It was the study objective to evaluate whether chewing a 180 mg loading dose of ticagrelor versus an equal dose of traditional oral administration, enhances inhibition of platelet aggregation 1 hour (h) after administering a… read more here.
Keywords: ticagrelor; nstemi patients; inhibition; group ... See more keywords
Inhalation with intravenous loading dose of colistin in critically ill patients with pneumonia caused by carbapenem-resistant gram-negative bacteria
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DOI: 10.1177/1753466619885529
Abstract: Background: Despite the increasing use of colistin in clinical practice, the optimal dosing, and administration route have not been established. This study aimed to evaluate the clinical outcome and safety of intravenous (IV) colistin with… read more here.
Keywords: colistin; ill patients; critically ill; carbapenem resistant ... See more keywords