Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50875
Abstract: To identify clinicopathological differences between frontotemporal lobar degeneration (FTLD) due to mutations in progranulin (FTLD‐GRN) and chromosome 9 open reading frame 72 (FTLD‐C9ORF72). read more here.
Keywords: c9orf72; frontotemporal lobar; microglia frontotemporal; lobar degeneration ... See more keywords
TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.03.008
Abstract: BACKGROUND Neurodegenerative diseases involving protein aggregation often accompany psychiatric symptoms. Frontotemporal lobar degeneration (FTLD) associated with TAR DNA-binding protein 43 (TDP-43) aggregation is characterized by progressive neuronal atrophy in frontal and temporal lobes of cerebral… read more here.
Keywords: protein; local translation; lobar degeneration; coaggregation ... See more keywords
Geschwind Syndrome in frontotemporal lobar degeneration: Neuroanatomical and neuropsychological features over 9 years
Sign Up to like & getrecommendations! Published in 2017 at "Cortex"
DOI: 10.1016/j.cortex.2017.06.003
Abstract: Geschwind Syndrome, a characteristic behavioral syndrome frequently described in patients affected by temporal lobe epilepsy (TLE), consists of the following features: hyper-religiosity, hypergraphia, hyposexuality, and irritability. Here we report the 9-year-clinical course of a case… read more here.
Keywords: geschwind syndrome; frontotemporal lobar; lobar degeneration;
The association between repeat number in C9orf72 and phenotypic variability in Turkish patients with frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.12.007
Abstract: Frontotemporal lobar degeneration (FTLD) describes a group of progressive brain disorders. The expansion of a noncoding GGGGCC (G4C2) hexanucleotide repeat in the C9orf72 gene is a major cause of both familial FTLD and amyotrophic lateral… read more here.
Keywords: turkish patients; repeat; lobar degeneration; c9orf72 ... See more keywords
Assessing circular RNAs in Alzheimer's disease and frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.03.017
Abstract: A circular-transcriptome-wide study has recently linked differential expression of circular RNAs (circRNAs) in brain tissue with Alzheimer's disease (AD). We aimed at replicating the major findings in an independent series of sporadic and familial AD.… read more here.
Keywords: circular rnas; alzheimer disease; lobar degeneration; expression ... See more keywords
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.10.012
Abstract: Highlights • We report MR-spectroscopy in syndromes linked to frontotemporal lobar degeneration (FTLD).• NAA and glutamate concentrations in the frontal lobe are reduced by FTLD.• NAA and glutamate levels correlate with behavior in FTLD-related syndromes. read more here.
Keywords: lobar degeneration; frontotemporal lobar; spectroscopy; related syndromes ... See more keywords
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01384-8
Abstract: Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers or effective disease-modifying therapies exist for the different clinical or genetic subtypes of FTLD.… read more here.
Keywords: deficient neurotransmitter; neurotransmitter systems; frontotemporal lobar; lobar degeneration ... See more keywords
The changing landscape of neuroimaging in frontotemporal lobar degeneration: from group-level observations to single-subject data interpretation
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2022.2048648
Abstract: ABSTRACT Introduction While the imaging signatures of frontotemporal lobar degeneration (FTLD) phenotypes and genotypes are well-characterized based on group-level descriptive analyses, the meaningful interpretation of single MRI scans remains challenging. Single-subject MRI classification frameworks rely… read more here.
Keywords: subject data; frontotemporal lobar; data interpretation; interpretation ... See more keywords
GABAergic cortical network physiology in frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab097
Abstract: Abstract The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous, including the behavioural variant frontotemporal dementia (bvFTD) and progressive supranuclear palsy. Although pathologically distinct, they share many behavioural, cognitive and physiological features, which may… read more here.
Keywords: physiology; frontotemporal lobar; gaba; lobar degeneration ... See more keywords
Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaa045
Abstract: Atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions (aFTLD-U) is an uncommon cause of frontotemporal dementia characterized by fused in sarcoma-positive inclusions. It is classified as a subtype of frontotemporal lobar degeneration with FUS pathology. Cases… read more here.
Keywords: frontotemporal lobar; degeneration fus; lobar degeneration; pathology ... See more keywords
Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-017-0432-x
Abstract: An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat… read more here.
Keywords: bidirectional nucleolar; frontotemporal lobar; repeat; lobar degeneration ... See more keywords