Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51793
Abstract: OBJECTIVE Typical aging is associated with gradual cognitive decline and changes in brain structure. The observation that cognitive performance in mesial temporal lobe epilepsy (TLE) patients diverges from controls early in life with subsequent decline… read more here.
Keywords: white matter; brain volumes; brain; lobe epilepsy ... See more keywords
Stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25180
Abstract: To evaluate the outcomes 1 year and longer following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a large series of patients treated over a 5‐year period since introduction of this novel technique. read more here.
Keywords: lobe epilepsy; mesial temporal; amygdalohippocampotomy mesial; temporal lobe ... See more keywords
Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26581
Abstract: Genetic factors have long been debated as a cause of failure of surgery for mesial temporal lobe epilepsy (MTLE). We investigated whether rare genetic variation influences seizure outcomes of MTLE surgery. read more here.
Keywords: surgery; lobe epilepsy; rare genetic; temporal lobe ... See more keywords
Selective neuronal knockout of STAT3 function inhibits epilepsy progression, improves cognition, and restores dysregulated gene networks in a temporal lobe epilepsy model.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26644
Abstract: OBJECTIVE Temporal lobe epilepsy (TLE) is a progressive disorder mediated by pathological changes in molecular cascades and hippocampal neural circuit remodeling that results in spontaneous seizures and cognitive dysfunction. Targeting these cascades may provide disease-modifying… read more here.
Keywords: progression; lobe epilepsy; stat3; temporal lobe ... See more keywords
Disrupted female estrous cyclicity in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia Open"
DOI: 10.1002/epi4.12026
Abstract: Reproductive dysfunction is a comorbidity that commonly occurs with temporal lobe epilepsy (TLE). Characterization of this comorbidity in various models of TLE in mice will greatly facilitate mechanistic investigations of the relationship between reproductive disorders… read more here.
Keywords: cyclicity intrahippocampal; lobe epilepsy; estrous cyclicity; intrahippocampal kainic ... See more keywords
Widespread abnormalities in white matter integrity and their relationship with duration of illness in temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia Open"
DOI: 10.1002/epi4.12222
Abstract: Elucidation of abnormal connections throughout the whole brain is necessary to understand temporal lobe epilepsy (TLE). We examined abnormalities in whole‐brain white matter integrity and their relationship with duration of illness in patients with TLE. read more here.
Keywords: temporal lobe; lobe epilepsy; relationship duration; integrity relationship ... See more keywords
Glymphatic system dysfunction in temporal lobe epilepsy patients with hippocampal sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12594
Abstract: This study aimed to evaluate glymphatic system function in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS) in comparison to healthy controls, using diffusion tensor imaging (DTI)‐analysis along the perivascular space (ALPS) method. We… read more here.
Keywords: system; patients hippocampal; lobe epilepsy; temporal lobe ... See more keywords
Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12645
Abstract: Psychosis is an important comorbidity in epilepsy, but its pathophysiology is still unknown. The imaging modality 18F‐fluorodeoxyglucose‐positron emission tomography (18F‐FDG PET) is widely used to measure brain glucose metabolism, and we speculated that 18F‐FDG PET… read more here.
Keywords: lobe epilepsy; temporal lobe; upper cerebellar; epilepsy ... See more keywords
Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12679
Abstract: High‐resolution (1 mm isotropic) diffusion tensor imaging (DTI) of the hippocampus in temporal lobe epilepsy (TLE) patients has shown patterns of hippocampal subfield diffusion abnormalities, which were consistent with hippocampal sclerosis (HS) subtype on surgical histology.… read more here.
Keywords: diffusion; lobe epilepsy; temporal lobe; pathology ... See more keywords
The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12727
Abstract: We aimed to explore the underlying pathomechanisms of the comorbidity between three common systemic autoimmune disorders (SADs) [i.e., insulin‐dependent diabetes mellitus (IDDM), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA)] and temporal lobe epilepsy (TLE),… read more here.
Keywords: temporal lobe; autoimmune disorders; systemic autoimmune; lobe epilepsy ... See more keywords
Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24530
Abstract: Mesial temporal lobe epilepsy (TLE) is a common neurological disorder affecting the hippocampus and surrounding medial temporal lobe (MTL). Although prior studies have analyzed whole‐brain network distortions in TLE patients, the functional network architecture of… read more here.
Keywords: lobe epilepsy; network; asymmetry; mri ... See more keywords