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Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45316
Abstract: Local anaesthetics (LAs) may lead to neurological complications, but the underlying mechanism is still unclear. Many neurotoxicity research studies have examined different LAs, but none have comprehensively explored the distinct mechanisms of neurotoxicity caused by…
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Keywords:
ester procaine;
amide bupivacaine;
local anaesthetics;
neurotoxicity ... See more keywords
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Published in 2022 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000001204
Abstract: Purpose of review The duration of single-injection regional anaesthesia is limited due to the inherent pharmacological properties of local anaesthetics. The ideal duration of a regional anaesthesia block lasting for the first 24 h postoperatively can…
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Keywords:
regional anaesthesia;
prolong duration;
anaesthesia;
local anaesthetics ... See more keywords
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Published in 2021 at "Anaesthesia"
DOI: 10.1111/anae.15641
Abstract: Various techniques have been explored to prolong the duration and improve the efficacy of local anaesthetic nerve blocks. Some of these involve mixing local anaesthetics or adding adjuncts. We did a literature review of studies…
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Keywords:
review;
local anaesthetics;
local anaesthetic;
pharmacological clinical ... See more keywords
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Published in 2018 at "International Endodontic Journal"
DOI: 10.1111/iej.12899
Abstract: The acidic nature of commercial local anaesthetics (LAs) can cause pain during infiltration and delay the onset of anaesthesia. It is suggested that adjusting the pH of anaesthetic agents could minimize these effects. This systematic…
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Keywords:
systematic review;
local anaesthetics;
time;
review ... See more keywords
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Published in 2017 at "BMC Veterinary Research"
DOI: 10.1186/s12917-017-1244-8
Abstract: BackgroundChondrotoxic effects of local anaesthetics are well reported in humans and some animal species but knowledge on their toxic effects on synoviocytes or equine chondrocytes or the effects on cellular production of inflammatory cytokines is…
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Keywords:
cell viability;
combination;
local anaesthetics;
morphine mgso4 ... See more keywords
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Published in 2017 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v5.i8.307
Abstract: Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or…
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Keywords:
adjuvants local;
local anaesthetics;
local anesthetics;
current understanding ... See more keywords