Neurotoxicity Comparison of Two Types of Local Anaesthetics: Amide-Bupivacaine versus Ester-Procaine
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DOI: 10.1038/srep45316
Abstract: Local anaesthetics (LAs) may lead to neurological complications, but the underlying mechanism is still unclear. Many neurotoxicity research studies have examined different LAs, but none have comprehensively explored the distinct mechanisms of neurotoxicity caused by… read more here.
Keywords: ester procaine; amide bupivacaine; local anaesthetics; neurotoxicity ... See more keywords
Measures to prolong duration of sensory block after regional anaesthesia
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DOI: 10.1097/aco.0000000000001204
Abstract: Purpose of review The duration of single-injection regional anaesthesia is limited due to the inherent pharmacological properties of local anaesthetics. The ideal duration of a regional anaesthesia block lasting for the first 24 h postoperatively can… read more here.
Keywords: regional anaesthesia; prolong duration; anaesthesia; local anaesthetics ... See more keywords
Pharmacological and clinical implications of local anaesthetic mixtures: a narrative review
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DOI: 10.1111/anae.15641
Abstract: Various techniques have been explored to prolong the duration and improve the efficacy of local anaesthetic nerve blocks. Some of these involve mixing local anaesthetics or adding adjuncts. We did a literature review of studies… read more here.
Keywords: review; local anaesthetics; local anaesthetic; pharmacological clinical ... See more keywords
The effect of adjusting the pH of local anaesthetics in dentistry: a systematic review and meta‐analysis
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DOI: 10.1111/iej.12899
Abstract: The acidic nature of commercial local anaesthetics (LAs) can cause pain during infiltration and delay the onset of anaesthesia. It is suggested that adjusting the pH of anaesthetic agents could minimize these effects. This systematic… read more here.
Keywords: systematic review; local anaesthetics; time; review ... See more keywords
Local anaesthetics or their combination with morphine and/or magnesium sulphate are toxic for equine chondrocytes and synoviocytes in vitro
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DOI: 10.1186/s12917-017-1244-8
Abstract: BackgroundChondrotoxic effects of local anaesthetics are well reported in humans and some animal species but knowledge on their toxic effects on synoviocytes or equine chondrocytes or the effects on cellular production of inflammatory cytokines is… read more here.
Keywords: cell viability; combination; local anaesthetics; morphine mgso4 ... See more keywords
Adjuvants to local anesthetics: Current understanding and future trends
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DOI: 10.12998/wjcc.v5.i8.307
Abstract: Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or… read more here.
Keywords: adjuvants local; local anaesthetics; local anesthetics; current understanding ... See more keywords