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Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200246
Abstract: Local anesthetics occupy a prime position in clinical medicine as they temporarily relieve the pain by blocking voltage‐gated sodium channels. However, limited structural diversity, problems with the efficiency of syntheses and increasing toxicity, mean that…
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Keywords:
multicomponent reactions;
methodology;
local anesthetics;
via multicomponent ... See more keywords
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Published in 2018 at "Der Anaesthesist"
DOI: 10.1007/s00101-018-0453-2
Abstract: Besides the well-known analgesic effects of amide-linked local anesthetics exerted via the inhibition of the voltage-gated sodium channel, these substances also possess a certain number of properties, which bear the potential to positively influence the outcome…
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Keywords:
systemic effects;
amide linked;
linked local;
local anesthetics ... See more keywords
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Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02309-y
Abstract: In the last few decades, several formulations have evolved to realize better efficacy of administered anesthesia. These innovative formulations have facilitated surgeons to perform operations under purely local anesthesia, which provides extra protection and comfort…
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Keywords:
safety efficacy;
delivery;
efficacy;
local anesthetics ... See more keywords
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Published in 2022 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2022.103480
Abstract: Background Adding ketamine to local anesthetics used for caudal block in children is an emerging clinical practice. This review aims to resolve controversies related to this adjuvant for a caudal block in children who underwent…
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Keywords:
caudal block;
local anesthetics;
used caudal;
block ... See more keywords
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Published in 2017 at "AORN Journal"
DOI: 10.1016/j.aorn.2017.08.015
Abstract: Abstract Local anesthetics are commonly used in the perioperative environment to facilitate surgical procedures or to provide postoperative pain management for patients. The use of local anesthetics, however, introduces the risk of complications resulting from…
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Keywords:
anesthetic systemic;
toxicity;
local anesthetics;
local anesthetic ... See more keywords
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Published in 2018 at "Annals of Physical and Rehabilitation Medicine"
DOI: 10.1016/j.rehab.2018.05.190
Abstract: Introduction/Background Ropivacaine, bupivacaine and triamcinolone are used daily in injections during surgeries and pain therapy. The purpose was to analyze the ability of local anesthetics and cortisone to induce apoptosis and necrosis in fibroblasts, tenocytes…
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Keywords:
necrosis;
apoptosis;
local anesthetics;
bupivacaine ... See more keywords
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Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0067-x
Abstract: Lappaconitine (LA) has been widely used for postoperative and cancer pain control. LA exhibits excellent analgesic activity with a longer effective time than common local anesthetics such as tetracaine and bupivacaine. However, the mechanisms underlying…
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Keywords:
voltage;
local anesthetics;
analgesic activity;
gated sodium ... See more keywords
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Published in 2019 at "Pain medicine"
DOI: 10.1093/pm/pnz139
Abstract: BACKGROUND Surgery in concert with anesthesia is a key part of the management of advanced-stage cancers. Anesthetic agents such as opioids and volatile anesthetics have been shown to promote recurrence in preclinical models, whereas some…
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Keywords:
recurrence;
mechanisms action;
local anesthetics;
review ... See more keywords
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Published in 2017 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000000492
Abstract: Purpose of review There is ongoing controversy regarding the tumor-protective effects of regional anesthesia in patients undergoing cancer surgery. Evidence of up-to-date systematic reviews will be presented alongside recent updates on the effects of opioids…
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Keywords:
regional anesthesia;
anesthesia;
local anesthetics;
effects regional ... See more keywords
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Published in 2017 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000000887
Abstract: BACKGROUND The specialty of dermatology relies heavily on local anesthesia for diagnosis and management of skin disease. The appropriate selection, preparation, administration, and monitoring of these medications affect surgical outcome and patient safety and satisfaction.…
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Keywords:
cutaneous surgery;
dermatology;
local anesthetics;
review ... See more keywords
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Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029358
Abstract: Background: Post COVID-19 syndrome (PC-19S) appears to be independent of acute illness severity and humoral response. The involvement of the autonomic nervous system (ANS), expressed by dysautonomia, has been hypothesized as a contributor. Several studies…
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Keywords:
therapeutic tool;
local anesthetics;
post covid;
patient ... See more keywords