Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2016.10.002
Abstract: Many mechanisms contribute to the secondary injury cascades following traumatic spinal cord injury (SCI). However, most current treatment strategies only target one or a few elements in the injury cascades, and have been largely unsuccessful… read more here.
Keywords: delivery; self assembled; local delivery; injury ... See more keywords
Prevention of irradiation-induced damage to salivary glands by local delivery of adipose-derived stem cells via hyaluronic acid-based hydrogels
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2020.06.014
Abstract: Abstract Most patients with head and neck cancer experience salivary gland dysfunction after chemo- and radiotherapies. There is currently no available treatment for this condition. Intervention with stem cell therapy has emerged as a promising… read more here.
Keywords: local delivery; stem; stem cells; salivary gland ... See more keywords
Proof of Principle for Local Delivery of a c-Met Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.10.025
Abstract: The reported proof of principle study demonstrated the feasibility of local delivery of a c-Met inhibitor (VXc-140) in a subcutaneous xenograft tumor model. VXc-140 was formulated in a wafer delivery system for direct implantation into… read more here.
Keywords: delivery met; delivery; vxc 140; local delivery ... See more keywords
Thermoresponsive Hydrogel-Based Local Delivery of Simvastatin for the Treatment of Periodontitis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c01196
Abstract: Except for routine scaling and root planing, there are few effective nonsurgical therapeutic interventions for periodontitis and associated alveolar bone loss. Simvastatin (SIM), one of the 3-hydroxy-3-methylglutaryl-cosenzyme A reductase inhibitors, which is known for its… read more here.
Keywords: thermoresponsive hydrogel; bone; sim; local delivery ... See more keywords
Novel Collagen Surgical Patches for Local Delivery of Multiple Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00048
Abstract: Effective control of post-operative inflammation after tissue repair remains a clinical challenge. A tissue repair patch that could appropriately integrate into the surrounding tissue and control inflammatory responses would improve tissue healing. A collagen-based hybrid… read more here.
Keywords: collagen; local delivery; multiple drugs; drug ... See more keywords
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity
Sign Up to like & getrecommendations! Published in 2024 at "Nature Immunology"
DOI: 10.1038/s41590-024-01925-7
Abstract: Systemically administered cytokines are potent immunotherapeutics but can cause severe dose-limiting toxicities. To overcome this challenge, cytokines have been engineered for intratumoral retention after local delivery. However, despite inducing regression of treated lesions, tumor-localized cytokines… read more here.
Keywords: systemic antitumor; cd45; local delivery; targeted immunocytokines ... See more keywords
Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18436-1
Abstract: Broad use of germline testing has identified an increasing number of women at risk for breast cancer with a need for effective chemoprevention. We report a novel method to selectively deliver various anti-estrogens at high… read more here.
Keywords: local delivery; silastic tubing; breast cancer;
Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm00896j
Abstract: Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a very poor prognosis. The standard treatment for newly diagnosed patients involves total tumor surgical resection (if possible), plus irradiation and adjuvant… read more here.
Keywords: malignant brain; delivery; local delivery; adjuvant ... See more keywords
Polymer nanocarriers for targeted local delivery of agents in treating brain tumors
Sign Up to like & getrecommendations! Published in 2022 at "Nanotechnology"
DOI: 10.1088/1361-6528/ac9683
Abstract: Glioblastoma (GBM), the deadliest brain cancer, presents a multitude of challenges to the development of new therapies. The standard of care has only changed marginally in the past 17 years, and few new chemotherapies have… read more here.
Keywords: nanotechnology; nanocarriers targeted; brain; local delivery ... See more keywords
Local Delivery of Therapeutic Boron for Bone Healing Enhancement.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of orthopaedic trauma"
DOI: 10.1097/bot.0000000000001974
Abstract: OBJECTIVES To evaluate if local delivery of boron can accelerate bone healing and examine if the bioactive salt impacts the osteogenic response of bone-derived osteoclasts and osteoblasts by the regulation of the Wnt/β-catenin pathway. METHODS… read more here.
Keywords: catenin; boron; local delivery; activity ... See more keywords
Local Delivery of Adipose Stem Cell Promotes Allograft Survival in A Rat Hind Limb Model of Vascularized Composite Allotransplantation.
Sign Up to like & getrecommendations! Published in 2023 at "Plastic and reconstructive surgery"
DOI: 10.1097/prs.0000000000010510
Abstract: BACKGROUND Adipose stem cells (ASCs) are a promising cell-based immunotherapy due to their minimally invasive harvest, high yield, and immunomodulatory capacity. In this study, we investigated the effects of local vs. systemic ASC delivery on… read more here.
Keywords: cell; local delivery; adipose stem; allograft survival ... See more keywords