Local Drug Delivery Techniques for Triggering Immunogenic Cell Death.
Sign Up to like & getrecommendations! Published in 2023 at "Small methods"
DOI: 10.1002/smtd.202300347
Abstract: Immunogenic cell death (ICD), a dying state of the cells, encompasses the changes in the conformations of cell surface and the release of damage-associated molecular patterns, which could initiate an adaptive immune response by stimulating… read more here.
Keywords: delivery techniques; immunogenic cell; local drug; drug delivery ... See more keywords
Recent advances in musculoskeletal local drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.01.043
Abstract: Musculoskeletal disorders are a significant burden on the global economy and public health. Advanced drug delivery plays a key role in the musculoskeletal field and holds the promise of enhancing the repair of degenerated and… read more here.
Keywords: local drug; drug delivery; musculoskeletal local; delivery ... See more keywords
Overcoming barriers by local drug delivery with liposomes.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.01.019
Abstract: Localized or topical administration of drugs may be considered as a potential approach for overcoming the problems caused by the various biological barriers encountered in drug delivery. The combination of using localized administration routes and… read more here.
Keywords: local drug; drug delivery; delivery; barriers local ... See more keywords
Nanoscale systems for local drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Nano today"
DOI: 10.1016/j.nantod.2019.100765
Abstract: Many diseases and conditions affect a relatively localized area of the body. They can be treated either by direct deposition of drug in the target area, or by giving the drug systemically. Here we review… read more here.
Keywords: local drug; systems local; drug delivery; nanoscale systems ... See more keywords
Lysine-derived, pH-sensitive and biodegradable poly(beta-aminoester urethane) networks and their local drug delivery behaviour.
Sign Up to like & getrecommendations! Published in 2018 at "Soft matter"
DOI: 10.1039/c7sm01886j
Abstract: In this study, a series of covalently crosslinked, l-lysine based poly(beta-aminoester urethane) (LPBAEU) networks with good biodegradability and pH sensitivity was reported. The effect of hydrophilic/hydrophobic characteristics and diacrylate/amine molar ratio on the structure, swelling… read more here.
Keywords: local drug; beta aminoester; aminoester urethane; lpbaeu networks ... See more keywords
Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr10329e
Abstract: Nanoengineered vehicles have the potential to deliver cargo drugs directly to disease sites, but can potentially be cleared by immune system cells or lymphatic drainage. In this study we explore the use of magnetism to… read more here.
Keywords: local drug; layer; layer layer; drug ... See more keywords
Stimuli-responsive local drug molecule delivery to adhered cells in a 3D nanocomposite scaffold
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Materials Chemistry B"
DOI: 10.1039/c9tb00591a
Abstract: pH-Responsive nanocomposite hydrogels deliver high dosages of drug to cancer cells while delivering less of the drug to healthy cells. read more here.
Keywords: drug molecule; responsive local; drug; local drug ... See more keywords
Bone tissue response following local drug delivery of bisphosphonate through titanium oxide nanotube implants in a rabbit model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Periodontology"
DOI: 10.1111/jcpe.12776
Abstract: OBJECTIVES The objective of this study was to evaluate whether surface chemistry-controlled TiO2 nanotube structures may serve as a local drug delivery system for zoledronic acid improving implant-bone support. METHODS Twenty-four screw-shaped Ti implants with… read more here.
Keywords: local drug; drug delivery; chemistry; bone ... See more keywords
Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1042128
Abstract: Chronic osteomyelitis is one of the most challenging diseases in orthopedic treatment. It is usually treated with intravenous antibiotics and debridement in clinical practice, which also brings systemic drug side effects and bone defects. The… read more here.
Keywords: osteomyelitis; local drug; treating chronic; delivery ... See more keywords
Recent progress of hydrogel-based local drug delivery systems for postoperative radiotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1027254
Abstract: Surgical resection and postoperative radiotherapy remained the most common therapeutic modalities for malignant tumors. However, tumor recurrence after receiving such combination is difficult to be avoided because of high invasiveness and radiation resistance of cancer… read more here.
Keywords: delivery systems; postoperative radiotherapy; local drug; drug delivery ... See more keywords
Establishment of a Rodent Glioblastoma Partial Resection Model for Chemotherapy by Local Drug Carriers—Sharing Experience
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11061518
Abstract: Local drug delivery systems (LDDS) represent a promising therapy strategy concerning the most common and malignant primary brain tumor glioblastoma (GBM). Nevertheless, to date, only a few systems have been clinically applied, and their success… read more here.
Keywords: local drug; resection model; resection; partial resection ... See more keywords