A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells
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DOI: 10.1016/j.cell.2021.05.028
Abstract: A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting host autoimmunity. We investigated homeostatic control of self-activated T cells within unperturbed tissue environments by combining high-resolution multiplexed and volumetric imaging with computational… read more here.
Keywords: regulatory cell; local regulatory; feedback; activated cells ... See more keywords