Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models
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DOI: 10.1038/s41593-025-02062-6
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by neuromuscular junction (NMJ) disruption and neurodegeneration. Recent findings highlight a pivotal role for TAR DNA-binding protein 43 (TDP-43) in forming axonal pathological condensates and facilitating NMJ disruption through… read more here.
Keywords: local synthesis; mir 126; synthesis; muscle derived ... See more keywords