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   Articles with "local therapy" as a keyword



Prior Local Therapy and First-Line Apalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer

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recommendations! Published in 2024 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2024.39434

Abstract: Key Points Question Does prior prostate-directed local therapy (LT) modify the response to subsequent androgen receptor pathway inhibitors (ARPIs) among patients with nonmetastatic castration-resistant prostate cancer (nmCRPC)? Findings In this secondary analysis of a randomized… read more here.

Keywords: patients nonmetastatic; prostate; local therapy; nonmetastatic castration ... See more keywords

Definitive local therapy to head and neck squamous cell carcinoma with distant metastasis

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recommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"

DOI: 10.1002/lio2.807

Abstract: Data on the efficacy of including definitive local therapy to the primary site for head and neck squamous cell carcinoma (HNSCC) patients with synchronous distant metastasis are lacking. In multiple different solid tumor types, there… read more here.

Keywords: head neck; local therapy; squamous cell; therapy ... See more keywords

A systematic review on the impact of delayed local therapy in patients with Ewing sarcoma of the pelvis

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recommendations! Published in 2025 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-025-06286-8

Abstract: Local treatment of pelvic Ewing Sarcoma (EWS) is czhallenging due to complex anatomy and potential complications. Local therapy may be deferred to maintain chemotherapy dose-intensity, but the impact of this delay on outcomes remains unclear.… read more here.

Keywords: delayed local; therapy; local therapy; systematic review ... See more keywords
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The Emerging Role of Local Therapy in Metastatic Prostate Cancer

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recommendations! Published in 2020 at "Current Oncology Reports"

DOI: 10.1007/s11912-020-0868-1

Abstract: Purpose of Review This review summarizes the prospective clinical evidence regarding local therapy in metastatic prostate cancer. Recent Findings The phase 3 STAMPEDE trial showed that prostate radiotherapy confers a survival benefit for newly diagnosed… read more here.

Keywords: prostate; therapy metastatic; local therapy; prostate cancer ... See more keywords
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P3.01-65 First-Line Radical Local Therapy May Provide Additional Survival Gain for Patients with EGFR-Mutant Metastatic NSCLC Receiving TKIs

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recommendations! Published in 2018 at "Journal of Thoracic Oncology"

DOI: 10.1016/j.jtho.2018.08.1625

Abstract: as different line therapies. The disease control rate of chemotherapy, immunotherapy, MKI group was 70.0%, 71.43% and 50%, respectively. While the median PFS of three groups was 2.50 months, 2.70 months, 0.30 months, respectively, which… read more here.

Keywords: line; first line; therapy may; line radical ... See more keywords

Yes or no to local therapy for oligometastatic prostate cancer?

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recommendations! Published in 2018 at "Nature Reviews Urology"

DOI: 10.1038/s41585-018-0028-7

Abstract: Metastatic prostate cancer has traditionally been treated with systemic therapy alone, but the issue of oligometastatic disease raises the question of whether local therapy — radical prostatectomy or prostate radiotherapy — should be performed. A… read more here.

Keywords: prostate; yes local; prostate cancer; local therapy ... See more keywords
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Prognostic impact of prior local therapy in castration-resistant prostate cancer.

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recommendations! Published in 2021 at "Japanese journal of clinical oncology"

DOI: 10.1093/jjco/hyab019

Abstract: OBJECTIVE This study aimed to reveal the prognostic values of prior local therapy in first-line therapy using androgen receptor-axis targeting agents (abiraterone or enzalutamide) or docetaxel for castration-resistant prostate cancer (CRPC). METHODS The study included… read more here.

Keywords: prostate cancer; prior local; local therapy; castration resistant ... See more keywords

Local therapy for oligometastatic prostate cancer.

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recommendations! Published in 2025 at "Japanese journal of clinical oncology"

DOI: 10.1093/jjco/hyaf048

Abstract: Traditionally, systemic therapy based on androgen deprivation therapy (ADT) has been the primary approach for treating metastatic prostate cancer. Local therapies targeting metastatic lesions have rarely been employed for cancer control. However, the advent of… read more here.

Keywords: cancer; oligometastatic prostate; prostate; local therapy ... See more keywords

Multidisciplinary treatment of advanced or metastatic ALK-positive non-small cell lung cancer: Real-world data on Brigatinib combined with local therapy

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recommendations! Published in 2025 at "Medicine"

DOI: 10.1097/md.0000000000042297

Abstract: Anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) often shows incomplete responses and progression despite tyrosine kinase inhibitor (TKI) therapy. Preliminary data suggest that combining brigatinib, an ALK-selective TKI, with surgery or radiotherapy may… read more here.

Keywords: brigatinib; treatment; therapy; local therapy ... See more keywords

Is radical local therapy effective in postoperative recurrent EGFR-mutated non-small cell lung cancer?

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recommendations! Published in 2023 at "Thoracic cancer"

DOI: 10.1111/1759-7714.14911

Abstract: BACKGROUND Long-term survival can be achieved with radical local therapy in some cases of postoperative recurrence of non-small cell lung cancer (NSCLC). Here, we evaluated post-recurrence survival (PRS) after treatment of postoperative recurrent epidermal growth… read more here.

Keywords: survival; local therapy; recurrence; radical local ... See more keywords

Definitive local therapy for T4 prostate cancer associated with improved local control and survival.

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recommendations! Published in 2023 at "BJU international"

DOI: 10.1111/bju.16027

Abstract: OBJECTIVES To evaluate clinical (c)T4 prostate cancer patients, which represent both a heterogenous and understudied population, who often present with locally advanced disease and obstructive symptoms causing significant morbidity and mortality. We analyzed whether receiving… read more here.

Keywords: prostate cancer; disease; local therapy; therapy ... See more keywords