In vitro and in vivo local tolerability of a synergistic anti‐tuberculosis drug combination intended for pulmonary delivery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4381
Abstract: A drug combination, vancomycin (VAN) plus tetrahydrolipstatin (THL), has demonstrated an effective synergistic action in vitro against Mycobacterium tuberculosis (Mtb). The poor oral bioavailability of VAN and THL and the predominant tropism of Mtb infection… read more here.
Keywords: local tolerability; van; anti tuberculosis; combination ... See more keywords
Ninety-day Local Tolerability and Toxicity Study of ND0612, a Novel Formulation of Levodopa/Carbidopa, Administered by Subcutaneous Continuous Infusion in Minipigs
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DOI: 10.1177/0192623317729891
Abstract: A 90-day study in Göttingen minipigs was conducted to test the local tolerability and systemic toxicity of ND0612, a novel aqueous solution of carbidopa (CD)/levodopa (LD) intended for the treatment of Parkinson’s disease by continuous… read more here.
Keywords: nd0612 novel; local tolerability; infusion; per site ... See more keywords
Subcutaneous administration of paracetamol—Good local tolerability in palliative care patients: An observational study
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DOI: 10.1177/0269216318772472
Abstract: Background: The subcutaneous route is widely used in both palliative care and geriatrics. Numerous compounds are administered by this route, including paracetamol. However, there is no recommendation on which to base this latter practice and,… read more here.
Keywords: administration; local tolerability; care patients; palliative care ... See more keywords