Moving messages in the developing brain—emerging roles for mRNA transport and local translation in neural stem cells
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12626
Abstract: The mammalian cerebral cortex is a complex brain structure integral to our higher cognition. During embryonic cortical development, radial glial progenitors (RGCs) produce neurons and serve as physical structures for migrating neurons. Recent discoveries highlight… read more here.
Keywords: local translation; developing brain; translation; messages developing ... See more keywords
The m6 A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202101329
Abstract: Messenger RNA m6 A modification is shown to regulate local translation in axons. However, how the m6 A codes in axonal mRNAs are read and decoded by the m6 A reader proteins is still unknown.… read more here.
Keywords: local translation; parallel fiber; readers ythdf1; ythdf1 ythdf2 ... See more keywords
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02205-y
Abstract: Mislocalization and abnormal deposition of TDP-43 into the cytoplasm (TDP-43 proteinopathy) is a hallmark in neurons of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the pathogenic mechanism of the diseases linked to… read more here.
Keywords: neuronal axons; protein; local translation; tdp ... See more keywords
TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.03.008
Abstract: BACKGROUND Neurodegenerative diseases involving protein aggregation often accompany psychiatric symptoms. Frontotemporal lobar degeneration (FTLD) associated with TAR DNA-binding protein 43 (TDP-43) aggregation is characterized by progressive neuronal atrophy in frontal and temporal lobes of cerebral… read more here.
Keywords: protein; local translation; lobar degeneration; coaggregation ... See more keywords
Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.11.013
Abstract: Summary Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control mechanisms remain elusive. Here we show that the extracellular cue Sema3A induces an initial burst in local translation that precisely… read more here.
Keywords: eif2 pathway; local translation; increase local; neural wiring ... See more keywords
Local translation of the Down syndrome cell adhesion molecule (DSCAM) mRNA in the vertebrate central nervous system
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurogenetics"
DOI: 10.1080/01677063.2017.1391250
Abstract: Abstract Local translation of synaptic mRNAs is an important process related to key aspects of central nervous system development and physiology, including dendritogenesis, axonal growth cone morphology and guidance and synaptic plasticity. Accordingly, local translation… read more here.
Keywords: local translation; nervous system; central nervous; syndrome cell ... See more keywords
Local translation in primary afferents and its contribution to pain.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002658
Abstract: ABSTRACT Chronic pain remains a significant problem due to its prevalence, impact, and limited therapeutic options. Progress in addressing chronic pain is dependent on a better understanding of underlying mechanisms. While the available evidence suggests… read more here.
Keywords: signaling molecules; local translation; primary afferents; chronic pain ... See more keywords
The Differences in Local Translatome across Distinct Neuron Types Is Mediated by Both Baseline Cellular Differences and Post-transcriptional Mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "eNeuro"
DOI: 10.1523/eneuro.0320-18.2018
Abstract: Abstract Local translation in neurites is a phenomenon that enhances the spatial segregation of proteins and their functions away from the cell body, yet it is unclear how local translation varies across neuronal cell types.… read more here.
Keywords: local translation; post transcriptional; cell types; differences local ... See more keywords
Local translation in neuronal compartments: how local is local?
Sign Up to like & getrecommendations! Published in 2017 at "EMBO reports"
DOI: 10.15252/embr.201744045
Abstract: Efficient neuronal function depends on the continued modulation of the local neuronal proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at specific neuronal regions. Various aspects of translation such as… read more here.
Keywords: local translation; local local; neuronal compartments; compartments local ... See more keywords
The Coordination of Local Translation, Membranous Organelle Trafficking, and Synaptic Plasticity in Neurons
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.711446
Abstract: Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic proteome, enabling… read more here.
Keywords: local translation; translation membranous; translation; coordination local ... See more keywords
Local Translation Across Neural Development: A Focus on Radial Glial Cells, Axons, and Synaptogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.717170
Abstract: In the past two decades, significant progress has been made in our understanding of mRNA localization and translation at distal sites in axons and dendrites. The existing literature shows that local translation is regulated in… read more here.
Keywords: radial glial; local translation; translation across; neural development ... See more keywords