Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.
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DOI: 10.1016/j.str.2021.10.001
Abstract: Peroxiredoxins are ubiquitous enzymes that detoxify peroxides and regulate redox signaling. During catalysis, a "peroxidatic" cysteine (CP) in the conserved active site reduces peroxide while being oxidized to a CP-sulfenate, prompting a local unfolding event… read more here.
Keywords: native state; local unfolding; catalysis; active site ... See more keywords