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Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113381
Abstract: KRAS plays an essential role in regulating cell proliferation, differentiation, migration and survival. Mutated KRAS is a major driver of malignant transformation in multiple human cancers. We showed previously that fendiline (6) is an effective…
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Keywords:
membrane localization;
localization inhibitors;
scaffold repurposing;
kras plasma ... See more keywords