Alterations in Somatic Driver Genes Are Associated with Response to Neoadjuvant FOLFIRINOX in Patients with Localized Pancreatic Ductal Adenocarcinoma.
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DOI: 10.1097/xcs.0000000000000212
Abstract: BACKGROUND There is increased use of neoadjuvant fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) in the management of localized pancreatic ductal adenocarcinoma (PDAC), yet there are few validated biomarkers of treatment response. STUDY DESIGN Consecutive patients… read more here.
Keywords: localized pancreatic; ductal adenocarcinoma; neoadjuvant folfirinox; pancreatic ductal ... See more keywords
Impact of KRAS alterations in localized pancreatic cancer (PC).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.3_suppl.431
Abstract: 431Background: Patients (pts) with localized PC do not routinely undergo comprehensive genomic profiling (CGP) unless they develop recurrent or metastatic disease. KRAS is the most frequently mutat... read more here.
Keywords: alterations localized; kras alterations; localized pancreatic; oncology ... See more keywords
ASO Author Reflections: The Sequential Radiographic Effects of Preoperative Chemotherapy and (Chemo)Radiation on Tumor Anatomy in Patients with Localized Pancreatic Cancer
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DOI: 10.1245/s10434-020-08531-5
Abstract: Radiographic downstaging of localized pancreatic adenocarcinoma has historically been an uncommon event following preoperative therapy. We previously identified only one patient among 122 who had a borderline resectable tumor that was downstaged to resectable after… read more here.
Keywords: chemotherapy; localized pancreatic; chemo radiation; anatomy ... See more keywords
Upfront Chemotherapy Followed by Stereotactic Body Radiation Therapy with or without Surgery in Older Patients with Localized Pancreatic Cancer: A Single Institution Experience and Review of the Literature
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DOI: 10.3390/curroncol29010028
Abstract: Objective: To report on clinical outcomes and toxicity in older (age ≥ 70 years) patients with localized pancreatic cancer treated with upfront chemotherapy followed by stereotactic body radiation therapy (SBRT) with or without surgery. Methods:… read more here.
Keywords: localized pancreatic; pancreatic cancer; older patients; therapy ... See more keywords