Application of an iPSC‐Derived Organoid Model for Localized Scleroderma Therapy
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DOI: 10.1002/advs.202106075
Abstract: Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis, inflammatory infiltration, microvascular alterations, and epidermal appendage lesions. However, a deeper understanding of the pathogenesis and treatment strategies of LoS is currently limited.… read more here.
Keywords: application; localized scleroderma; therapy; los skin ... See more keywords
Sarcopenia in juvenile localized scleroderma: new insights on deep involvement
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DOI: 10.1007/s00330-020-06764-2
Abstract: Objectives Juvenile localized scleroderma (JLS) is a rare chronic autoimmune disease which can also affect bones and muscles. Nevertheless, muscle loss was not previously investigated in patients with JLS. Thus, the aim of this study… read more here.
Keywords: sarcopenia; deep involvement; muscle; localized scleroderma ... See more keywords
Development of minimum standards of care for juvenile localized scleroderma
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DOI: 10.1007/s00431-018-3144-8
Abstract: Juvenile localized scleroderma (jLS), also known as morphea, is an orphan disease. Pediatric guidelines regarding diagnosis, assessment, and management are lacking.Our objective was to develop minimum standards of care for diagnosis, assessment, and management of… read more here.
Keywords: localized scleroderma; management; juvenile localized; care ... See more keywords
Abnormal expression of interleukin-6 is associated with epidermal alternations in localized scleroderma
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Rheumatology"
DOI: 10.1007/s10067-022-06127-w
Abstract: Localized scleroderma (LSc) is a disease characterized by the excessive deposition of collagen and thereby thickening of the dermis. In recent years, studies reported that LSc demonstrated compromised skin barrier related to the progression of… read more here.
Keywords: localized scleroderma; skin; lesion; mouse model ... See more keywords
Neurological abnormalities in localized scleroderma of the face and head: a case series study for evaluation of imaging findings and clinical course
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DOI: 10.1080/00207454.2016.1244823
Abstract: Abstract Introduction: Localized scleroderma (LoS) of the face and head is often associated with neurological manifestations and/or imaging abnormalities in the central nervous system (CNS). Case series: We present an analysis of 20 cases of… read more here.
Keywords: head; localized scleroderma; case series; course ... See more keywords
Treatment of juvenile localized scleroderma: current recommendations, response factors, and potential alternative treatments
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DOI: 10.1097/bor.0000000000000886
Abstract: Purpose of review Juvenile localized scleroderma (jLS) is a chronic autoimmune and fibrosing disease associated with a high risk for functional impairment. Antifibrotic options are limited, so current treatment strategies are focused on disease activity… read more here.
Keywords: localized scleroderma; alternative treatments; juvenile localized; potential alternative ... See more keywords
Supportive Use of Adipose-Derived Stem Cells in Cell-Assisted Lipotransfer for Localized Scleroderma
Sign Up to like & getrecommendations! Published in 2018 at "Plastic and Reconstructive Surgery"
DOI: 10.1097/prs.0000000000004386
Abstract: Background: The authors aimed to analyze factors related to lipotransfer for localized scleroderma, and to explore the feasibility of cell-assisted lipotransfer for localized scleroderma treatment. Methods: Abdominal fat samples were taken from six scleroderma patients… read more here.
Keywords: lipotransfer localized; localized scleroderma; scleroderma patients; cell assisted ... See more keywords
Refining the hidradenitis suppurativa Hurley staging system for mild, moderate and severe disease
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DOI: 10.1111/bjd.17769
Abstract: ized scleroderma: a retrospective analysis of 344 patients with paediatricor adult-onset disease. Br J Dermatol 2015; 172:722–8. 4 Martini G, Fadanelli G, Agazzi A et al. Disease course and long-term outcome of juvenile localized scleroderma:… read more here.
Keywords: localized scleroderma; hidradenitis suppurativa; disease; refining hidradenitis ... See more keywords
Localized scleroderma histologically characterized by liquefaction degeneration and upper dermis fibrosis: a possible association with chemotherapy
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DOI: 10.1111/ced.14216
Abstract: Localized scleroderma (LSc) or morphea is an autoimmune inflammatory disorder of the skin and underlying tissues, such as subcutaneous fat, fascia, muscles and bones, resulting in extensive fibrosis and irreversible deformity. Since linear scleroderma, a… read more here.
Keywords: characterized liquefaction; fibrosis; histologically characterized; localized scleroderma ... See more keywords
Localized scleroderma: clinical and epidemiological features with emphasis on adulthood‐ versus childhood‐onset disease differences
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.14197
Abstract: Localized scleroderma is a rare inflammatory skin disorder that affects the skin and sometimes underlying subcutaneous tissue, muscles or bones. The disease has two modes of onset: juvenile‐ (JLS) and adult‐onset (aLoS). Clinical features have… read more here.
Keywords: emphasis adulthood; localized scleroderma; features emphasis; scleroderma clinical ... See more keywords
Prospective evaluation of treatment response and disease reversibility of paediatric localized scleroderma (morphoea) to steroids and methotrexate using multi‐modal imaging
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16308
Abstract: Paediatric localized scleroderma is a severe inflammatory disorder associated with tissue atrophy, often leading to disability. Assessing disease activity and response to treatment has always been challenging and remains an important difficulty in clinical practice. read more here.
Keywords: response; paediatric localized; localized scleroderma; treatment ... See more keywords