Expression of Programmed Cell Death Ligand in Cutaneous Squamous Cell Carcinoma and Treatment of Locally Advanced Disease With Pembrolizumab
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2016.5118
Abstract: Importance Limited therapies are available in patients with inoperable locally advanced cutaneous squamous cell carcinoma (cSCC). Objective To determine the efficacy of programmed cell death 1 receptor (PD-1) inhibitors in locally advanced cSCC. Design, Setting,… read more here.
Keywords: treatment; expression; pembrolizumab; locally advanced ... See more keywords
Effect of Positron Emission Tomography Imaging in Women With Locally Advanced Cervical Cancer
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2018.2081
Abstract: Key Points Question In women with locally advanced carcinoma of the cervix who are candidates for chemotherapy and radiotherapy, does adding fludeoxyglucose F 18 positron emission tomography–computed tomography (PET-CT) to staging with CT of the… read more here.
Keywords: women locally; positron emission; locally advanced; emission tomography ... See more keywords
Evaluation of the Association of Perioperative UGT1A1 Genotype-Dosed gFOLFIRINOX With Margin-Negative Resection Rates and Pathologic Response Grades Among Patients With Locally Advanced Gastroesophageal Adenocarcinoma: A Phase 2 Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2019.21290
Abstract: Importance Patients with locally advanced gastroesophageal adenocarcinoma (ie, stage ≥T3 and/or node positive) have high rates of recurrence despite surgery and adjunctive perioperative therapies, which also have high toxicity profiles. Evaluation of pharmacogenomically dosed perioperative… read more here.
Keywords: ugt1a1 genotype; genotype; gastroesophageal; patients locally ... See more keywords
Response-Adapted Treatment Following Radiotherapy in Patients With Resectable Locally Advanced Hypopharyngeal Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.0165
Abstract: Key Points Question Is a response-adapted strategy based on early tumor response to radiotherapy associated with improved survival with a functional larynx in patients with resectable locally advanced hypopharyngeal carcinoma? Findings In this cohort study… read more here.
Keywords: locally advanced; radiotherapy; response adapted; patients resectable ... See more keywords
Analysis of Tumor Mutational Burden, Progression-Free Survival, and Local-Regional Control in Patents with Locally Advanced Non–Small Cell Lung Cancer Treated With Chemoradiation and Durvalumab
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.49591
Abstract: Key Points Question Is tumor mutational burden (TMB) associated with outcomes among patients with locally advanced unresectable non–small cell lung cancer (NSCLC) treated with definitive chemoradiation and consolidative durvalumab? Findings In this cohort study of… read more here.
Keywords: locally advanced; free survival; durvalumab; progression free ... See more keywords
Imaging Locally Advanced, Recurrent, and Metastatic Prostate Cancer: A Review
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.5840
Abstract: Importance Prostate cancer is the second leading cause of cancer deaths in US men. The course of prostate cancer is highly variable, and timely and accurate detection of clinically significant cancer is critical in positively… read more here.
Keywords: prostate cancer; imaging locally; cancer; locally advanced ... See more keywords
Potential of Prospective Particle Therapy Trials to Increase the Therapeutic Ratio for Locally Advanced Lung Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2017.2165
Abstract: Efforts to increase tumor control and minimize toxic effects to normal tissue have been long-sought goals in the treatment of patients with locally advanced solid tumors who receive multimodal therapeutic approaches. For patients with non–… read more here.
Keywords: particle therapy; particle; locally advanced; oncology ... See more keywords
Activity of Cabazitaxel in Metastatic or Inoperable Locally Advanced Dedifferentiated Liposarcoma: A Phase 2 Study of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG).
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.3218
Abstract: Importance Treatment options for patients with unresectable and/or metastatic dedifferentiated liposarcoma (DDLPS) are limited. New drugs are required. Objective To assess whether cabazitaxel demonstrated sufficient antitumor activity in patients with metastatic or inoperable locally advanced… read more here.
Keywords: locally advanced; metastatic inoperable; dedifferentiated liposarcoma; activity ... See more keywords
Outcomes of Vismodegib for Periocular Locally Advanced Basal Cell Carcinoma From an Open-label Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2020.1539
Abstract: Importance The outcomes of vismodegib treatment in a relatively large cohort of study participants with periocular locally advanced basal cell carcinoma (POLA-BCC) may guide physicians when considering this treatment. Objective To report the outcomes of… read more here.
Keywords: treatment; study; outcomes vismodegib; pola bcc ... See more keywords
Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13116
Abstract: Circulating tumor DNA (ctDNA) has demonstrated great potential as a non-invasive biomarker to assess minimal residual disease (MRD) and to profile tumor genotypes in patients with non-small cell lung cancer (NSCLC). However, little is known… read more here.
Keywords: early stage; locally advanced; stage locally; resection ... See more keywords
Meta‐analysis of the effect of extending the interval after long‐course chemoradiotherapy before surgery in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Surgery"
DOI: 10.1002/bjs.11220
Abstract: The current standard of care in locally advanced rectal cancer (LARC) is neoadjuvant long‐course chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). Surgery is conventionally performed approximately 6–8 weeks after nCRT. This study aimed to determine… read more here.
Keywords: surgery; rectal cancer; long course; course chemoradiotherapy ... See more keywords