Knockdown of Nuclear-Located Enhancer RNAs and Long ncRNAs Using Locked Nucleic Acid GapmeRs.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-4035-6_2
Abstract: The human genome is widely transcribed outside of protein-coding genes, producing thousands of noncoding RNAs from different subfamilies including enhancer RNAs. Functional studies to determine the role of individual genes are challenging with noncoding RNAs… read more here.
Keywords: locked nucleic; knockdown nuclear; noncoding rnas; enhancer rnas ... See more keywords
Exosome-based antisense locked nucleic acid delivery for inhibition of type II collagen degradation in chondrocyte
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2019.02.017
Abstract: Abstract MicroRNA-34a (miR-34a) suppression can block the progression of type II collagen decrease in chondrocytes for osteoarthritis (OA) treatment. Thus, exosomes, nano-sized extracellular vesicles, were developed as delivery vehicles for antisense miR-34a locked nucleic acid… read more here.
Keywords: type collagen; nucleic acid; collagen; delivery ... See more keywords
Modeling pK Shift in DNA Triplexes Containing Locked Nucleic Acids
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00741
Abstract: The protonation states for nucleic acid bases are difficult to assess experimentally. In the context of DNA triplex, the protonation state of cytidine in the third strand is particularly important, because it needs to be… read more here.
Keywords: dna; dna triplex; cytidine; third strand ... See more keywords
Synthesis and biological properties of triazole-linked locked nucleic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04092j
Abstract: We have synthesized and studied the biological and biophysical properties of triazole-linked ribo and xylo locked nucleic acid (LNA). The combination of LNA with the Isobe triazole linkage gave high binding affinity when incorporated at… read more here.
Keywords: triazole linked; properties triazole; synthesis biological; nucleic acid ... See more keywords