A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.
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DOI: 10.1038/s42003-022-03229-8
Abstract: Loss-of-function mutations in Kv7.1 often lead to long QT syndrome (LQTS), a cardiac repolarization disorder associated with arrhythmia and subsequent sudden cardiac death. The discovery of agonistic IKs modulators may offer a new potential strategy… read more here.
Keywords: kv7 channels; benzodiazepine activator; activator locks; locks kv7 ... See more keywords