Propofol but not dexmedetomidine produce locomotor sensitization via nitric oxide in rats
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05707-5
Abstract: Rationale The abused potential of some anesthetics has been debated. Measurement of locomotor sensitization is a better way to detect the neurobehavioral plasticity of addiction. Objectives The present study aims to explore whether propofol and… read more here.
Keywords: propofol dexmedetomidine; nitric oxide; locomotor sensitization; sensitization ... See more keywords
Evidence of memory generalization in contextual locomotor sensitization induced by amphetamine
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.10.018
Abstract: Graphical abstract Figure. No Caption available. HighlightsAfter 3 days of withdrawal, amphetamine sensitization is context‐dependent.After 28 days of withdrawal, animals expressed a generalized locomotor activity in novel context.Contextual generalization is prevented when sensitization was conducted… read more here.
Keywords: memory generalization; locomotor; locomotor sensitization; sensitization ... See more keywords
Investigating the reciprocal relationships between locomotor sensitization to ethanol and PTSD-like clusters in DBA/2J mice
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.111909
Abstract: BACKGROUND Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are two conditions that co-occur frequently. The mechanistic explanations of this co-morbidity are still unclear. The goal of this study was twofold. First to investigate… read more here.
Keywords: ethanol sensitization; locomotor sensitization; sensitization; ptsd ... See more keywords
Susceptibility to express amphetamine locomotor sensitization correlates with dorsolateral striatum bursting activity and GABAergic synapses in the globus pallidus
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.12.005
Abstract: Repeated psychostimulant administration results in behavioral sensitization, a process that is relevant in the early phases of drug addiction. Critically, behavioral sensitization is not observed in all subjects. Evidence shows that differential neuronal activity in… read more here.
Keywords: locomotor sensitization; sensitization; susceptibility; striatum ... See more keywords
Regulation of microRNA-29c in the nucleus accumbens modulates methamphetamine -induced locomotor sensitization in mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.01.007
Abstract: ABSTRACT Changes in microRNA (miRNA)‐mediated gene expression in the nucleus accumbens (NAc) may play important roles in regulating drug addiction. MiR‐29c is a highly expressed miRNA in the human and rodent nervous systems where it… read more here.
Keywords: induced locomotor; meth induced; expression; locomotor sensitization ... See more keywords
Reduced expression of ethanol sensitization by α3β4 nicotinic acetylcholine receptors in DBA/2J mice.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental and clinical psychopharmacology"
DOI: 10.1037/pha0000324
Abstract: Alcohol use disorder (AUD) is a leading cause of preventable death in the United States, however existing treatments are ineffective and produce aversive side effects such as nausea and fatigue. One potential therapeutic for AUD… read more here.
Keywords: nicotinic acetylcholine; dba mice; ethanol; expression ... See more keywords
Cocaine-induced locomotor sensitization associates with slow oscillatory firing of neurons in the ventral tegmental area
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21592-7
Abstract: The initiation of psychostimulant sensitization depends on the mesocorticolimbic dopamine (DA) system. Although many cellular adaptations has been reported to be associated with this addictive behavior, the overall influence of these adaptations on the network… read more here.
Keywords: non neurons; ventral tegmental; locomotor sensitization; cocaine ... See more keywords
Menthol enhances nicotine-induced locomotor sensitization and in vivo functional connectivity in adolescence
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881117719265
Abstract: Mentholated cigarettes capture a quarter of the US market, and are disproportionately smoked by adolescents. Menthol allosterically modulates nicotinic acetylcholine receptor function, but its effects on the brain and nicotine addiction are unclear. To determine… read more here.
Keywords: locomotor sensitization; menthol; nicotine induced; functional connectivity ... See more keywords
Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0227-17.2017
Abstract: Visual Abstract Alterations in thalamic dopamine (DA) or DA D2 receptors (D2Rs) have been measured in drug addiction and schizophrenia, but the relevance of thalamic D2Rs for behavior is largely unknown. Using in situ hybridization… read more here.
Keywords: dopamine receptors; d2rs; locomotor sensitization; cocaine ... See more keywords
Sodium Leak Channel in the Nucleus Accumbens Modulates Ethanol-Induced Acute Stimulant Responses and Locomotor Sensitization in Mice: A Brief Research Report
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.687470
Abstract: Ethanol can induce acute stimulant responses in animals and human beings. Moreover, repeated exposure to ethanol may produce increased sensitivity to its acute locomotor stimulant actions, a process referred to as locomotor sensitization. The molecular… read more here.
Keywords: stimulant responses; locomotor sensitization; responses locomotor; ethanol induced ... See more keywords
Bulleyaconitine A Inhibits Morphine-Induced Withdrawal Symptoms, Conditioned Place Preference, and Locomotor Sensitization Via Microglial Dynorphin A Expression
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.620926
Abstract: Bulleyaconitine A (BAA), a C19-diterpenoid alkaloid, has been prescribed as a nonnarcotic analgesic to treat chronic pain over four decades in China. The present study investigated its inhibition in morphine-induced withdrawal symptoms, conditioned place preference… read more here.
Keywords: morphine induced; induced withdrawal; expression; locomotor sensitization ... See more keywords