Chemotherapy for locoregionally advanced nasopharyngeal carcinoma: Who really needs it
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5497
Abstract: The CSCO and ASCO guidelines in 2021 recommend chemotherapy for stage III–IVA (8th edition of AJCC staging) nasopharyngeal carcinoma (NPC). Actually, patients with stage T3–4N0M0 are often excluded from various clinical trials of the locoregionally… read more here.
Keywords: nasopharyngeal carcinoma; advanced nasopharyngeal; locoregionally advanced; chemotherapy locoregionally ... See more keywords
Optimizing induction chemotherapy regimens for radiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma
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DOI: 10.1002/cam4.5707
Abstract: The optimal number of cycles of induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LANPC) remains unresolved. This study aimed to quantitatively assess the changes in gross tumor volumes (GTVs) and to select the most… read more here.
Keywords: advanced nasopharyngeal; induction chemotherapy; nasopharyngeal carcinoma; locoregionally advanced ... See more keywords
Editorial for “MRI‐Based Deep Learning Model for Distant Metastasis‐Free Survival in Locoregionally Advanced Nasopharyngeal Carcinoma”
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27358
Abstract: Since Roentgen’s first discovery of the X beam, medical imaging has evolved beyond dreams. By increasing the integration of artificial intelligence technologies in recent years, radiology imaging has brought the opportunity to evaluate quantitative imaging… read more here.
Keywords: locoregionally advanced; mri based; deep learning; free survival ... See more keywords
Nomogram for distant metastasis-free survival in patients with locoregionally advanced nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Strahlentherapie und Onkologie"
DOI: 10.1007/s00066-022-01926-1
Abstract: To develop and validate a nomogram to predict distant metastasis-free survival of patients with locoregionally advanced nasopharyngeal carcinoma. We collected the total clinical data of 820 nasopharyngeal carcinoma (NPC) patients, of whom 482 formed the… read more here.
Keywords: patients locoregionally; locoregionally advanced; cohort; nasopharyngeal carcinoma ... See more keywords
The Cisplatin Total Dose and Concomitant Radiation in Locoregionally Advanced Head and Neck Cancer: Any Recent Evidence for Dose Efficacy?
Sign Up to like & getrecommendations! Published in 2017 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-017-0482-0
Abstract: Opinion statementConcurrent chemoradiotherapy (CRT) with high-dose (100 mg/m2), single-agent cisplatin is considered the standard of care for locoregionally advanced head and neck cancer (LAHNC). Poor compliance often due to significant treatment-related toxicities observed during CRT regimen… read more here.
Keywords: locoregionally advanced; treatment; cisplatin; evidence ... See more keywords
Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial.
Sign Up to like & getrecommendations! Published in 2020 at "Nature medicine"
DOI: 10.1038/s41591-020-1085-z
Abstract: Preoperative immunotherapy with anti-PD1 plus anti-CTLA4 antibodies has shown remarkable pathological responses in melanoma1 and colorectal cancer2. In NABUCCO (ClinicalTrials.gov: NCT03387761), a single-arm feasibility trial, 24 patients with stage III urothelial cancer (UC) received two… read more here.
Keywords: plus nivolumab; urothelial cancer; trial; locoregionally advanced ... See more keywords
Influence of concurrent chemotherapy on locoregionally advanced nasopharyngeal carcinoma treated with neoadjuvant chemotherapy plus intensity-modulated radiotherapy: A retrospective matched analysis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59470-w
Abstract: Neoadjuvant chemotherapy (NAC) combined with intensity-modulated radiotherapy (IMRT) plus concurrent chemotherapy (CC) will be the new standard treatment for locoregionally advanced nasopharyngeal carcinoma (NPC) patients. However, many patients fail to receive CC for multiple reasons.… read more here.
Keywords: chemotherapy; locoregionally advanced; analysis; nac plus ... See more keywords
Treatment outcomes of induction chemotherapy combined with intensity-modulated radiotherapy and adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma in Southeast China
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DOI: 10.1097/md.0000000000027023
Abstract: Abstract Induction chemotherapy (IC) and adjuvant chemotherapy (AC) are used to enhance tumor locoregional control and support early treatment for distant metastases. However, optimum combinatorial treatment of these chemoradiotherapy regimens with radiotherapy in curing locoregionally… read more here.
Keywords: chemotherapy; treatment; induction chemotherapy; locoregionally advanced ... See more keywords
Neoadjuvant immunotherapy of locoregionally advanced solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005036
Abstract: Definitive management of locoregionally advanced solid tumors presents a major challenge and often consists of a combination of surgical, radiotherapeutic and systemic therapy approaches. Upfront surgical treatment with or without adjuvant radiotherapy carries the risks… read more here.
Keywords: immunotherapy; therapy; locoregionally advanced; neoadjuvant immunotherapy ... See more keywords
Characterization of the T-Cell Receptor Repertoire and Immune Microenvironment in Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck
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DOI: 10.1158/1078-0432.ccr-17-0103
Abstract: Purpose: Squamous cell carcinoma of the head and neck (SCCHN) is a lethal cancer with a suboptimal 5-year overall survival of approximately 50% with surgery and/or definitive chemoradiotherapy. Novel treatments are thus urgently awaited. Immunotherapy… read more here.
Keywords: patients locoregionally; locoregionally advanced; cell receptor; hpv ... See more keywords
Prognostic Value of Circulating Lipoprotein in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000491728
Abstract: Background/Aims: Lipoproteins have been reported to be associated with prognosis in various cancers; however, the prognostic value of lipoproteins in patients with nasopharyngeal carcinoma (NPC) remains largely unknown. We aim to asses the role of… read more here.
Keywords: mmol; locoregionally advanced; prognostic value; patients locoregionally ... See more keywords