PATH-56. LOSS OF HETEROZYGOSITY OF CDKN2A/B DEFINES AN AGGRESSIVE SUBSET OF RECURRENT, HIGH-GRADE MENINGIOMAS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0755
Abstract: Loss of heterozygosity (LOH) occurs when one gene allele is lost, leaving the cell with a single functional copy. This genetic alteration drives tumor progression by disabling critical regulatory pathways. Currently, CDKN2A/B homozygous loss is… read more here.
Keywords: loh; grade; meningiomas; cdkn2a loh ... See more keywords
Monitoring Level of Hypnosis Using Stationary Wavelet Transform and Singular Value Decomposition Entropy With Feedforward Neural Network
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Transactions on Neural Systems and Rehabilitation Engineering"
DOI: 10.1109/tnsre.2023.3264797
Abstract: Classifying the patient’s depth of anesthesia (LoH) level into a few distinct states may lead to inappropriate drug administration. To tackle the problem, this paper presents a robust and computationally efficient framework that predicts a… read more here.
Keywords: neural network; stationary wavelet; loh; wavelet transform ... See more keywords
Abstract A074: Correlation of homologous recombination deficiency (HRD) status by BROCA-HR sequencing with response to combination cediranib and olaparib in relapsed ovarian cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a074
Abstract: Background: The combination of cediranib (ced) and olaparib (olap) improves progression-free survival and overall response rates (ORR) in women with recurrent plat sensitive high-grade serous (HGS) ovarian cancer compared to olap alone. In this Phase… read more here.
Keywords: status; plat sensitive; hrd; cancer ... See more keywords
Impact of Symptoms of Late-Onset Hypogonadism as a Potential Driver of Presenteeism
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Men's Health"
DOI: 10.1177/15579883251343972
Abstract: Presenteeism, defined as attending work despite physical or mental health issues that impair full productivity, is a prevalent concern with significant implications for workplace efficiency and employee well-being. Testosterone, the primary male sex hormone, plays… read more here.
Keywords: loh; onset hypogonadism; late onset; impact symptoms ... See more keywords
Comparison of a 3-component genomic instability score to individual biomarker scores in classifying homologous recombination deficiency.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e15165
Abstract: e15165 Background: Ovarian tumors with defects in the homologous recombination (HR) pathway have improved treatment response to DNA-damaging agents. HR deficiency (HRD) status is calculated through biomarker scores like large scale state transitions (LST), telomeric… read more here.
Keywords: loh; tai; hrd status; status ... See more keywords
Adaptation by Loss of Heterozygosity in Saccharomyces cerevisiae Clones Under Divergent Selection
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DOI: 10.1534/genetics.119.302411
Abstract: Loss of heterozygosity (LOH) is observed during vegetative growth and reproduction of diploid genotypes through mitotic crossovers, aneuploidy caused by nondisjunction, and gene conversion. We aimed to test the role that LOH plays during adaptation… read more here.
Keywords: adaptation; loh; saccharomyces cerevisiae; loss heterozygosity ... See more keywords
TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v11.i7.551
Abstract: BACKGROUND Patients with stage II-III colorectal cancer (CRC) treated with adjuvant chemotherapy, gain a 25% survival benefit. In the context of personalized medicine, there is a need to identify patients with CRC who may benefit… read more here.
Keywords: kras braf; loh; risk; adjuvant chemotherapy ... See more keywords