The dynamics of loss of heterozygosity events in genomes
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Reports"
DOI: 10.1038/s44319-024-00353-w
Abstract: Genomic instability is a hallmark of tumorigenesis, yet it also plays an essential role in evolution. Large-scale population genomics studies have highlighted the importance of loss of heterozygosity (LOH) events, which have long been overlooked… read more here.
Keywords: loh events; genomic instability; loss heterozygosity;
Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac214
Abstract: Abstract The appearance of genomic variations such as loss of heterozygosity (LOH) has a significant impact on phenotypic diversity observed in a population. Recent large-scale yeast population genomic surveys have shown a high frequency of… read more here.
Keywords: ploidy level; spectrum; loss heterozygosity; loh events ... See more keywords
Multiple Stochastic Parameters Influence Genome Dynamics in a Heterozygous Diploid Eukaryotic Model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8070650
Abstract: The heterozygous diploid genome of Candida albicans displays frequent genomic rearrangements, in particular loss-of-heterozygosity (LOH) events, which can be seen on all eight chromosomes and affect both laboratory and clinical strains. LOHs, which are often… read more here.
Keywords: stress; multiple stochastic; heterozygous diploid; loh events ... See more keywords