Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-022-04205-5
Abstract: β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the major described β-secretase to generate Aβ peptides in Alzheimer’s disease (AD). However, all therapeutic attempts to block BACE1 activity and to improve AD symptoms have… read more here.
Keywords: lon mouse; app lon; lon; meprin ... See more keywords
A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108983
Abstract: Lon is an ATP-dependent protease belonging to the "ATPase associated with diverse cellular activities" (AAA+) protein family. In humans, Lon is translated as a precursor and imported into the mitochondria matrix through deletion of the… read more here.
Keywords: lon; protease; human mitochondrial; mitochondrial lon ... See more keywords
Importance of The Mitochondrial Lon Protease in Age- and Sex-Specific Adaptation to Oxidative Stress
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.049
Abstract: The Lon protease plays a key role in mitochondrial proteostasis. We find that young female D. melanogaster flies, but not males, adapt to very low and non-damaging (micromolar), signaling, levels of H2O2 through the CncC… read more here.
Keywords: lon; medicine; age; specific adaptation ... See more keywords
Structure and the mode of activity of Lon proteases from diverse organisms.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167504
Abstract: Lon proteases, members of the AAA+ superfamily of enzymes, are key components of the protein quality control system in bacterial cells, as well as in the mitochondria and other specialized organelles of higher organisms. These… read more here.
Keywords: lon proteases; lon; activity lon; mode activity ... See more keywords
LonB Protease Is a Novel Regulator of Carotenogenesis Controlling Degradation of Phytoene Synthase in Haloferax volcanii.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00809
Abstract: The membrane protease LonB is an essential protein in the archaeon Haloferax volcanii and globally impacts its physiology. However, natural substrates of the archaeal Lon protease have not been identified. The whole proteome turnover was… read more here.
Keywords: lon; degradation; protease; phytoene synthase ... See more keywords
Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170319
Abstract: The natural small molecule compound: 2,3,5,6-tetramethylpyrazine (TMP), is a major component of the Chinese medicine Chuanxiong, which has wide clinical applications in dilating blood vessels, inhibiting platelet aggregation and treating thrombosis. Recent work suggests that… read more here.
Keywords: lon; degradation; dna; tetramethylpyrazine ... See more keywords
Surgical "Safe Zone": Rapid Anatomical Identification of the Lesser Occipital Nerve.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of reconstructive microsurgery"
DOI: 10.1055/s-0038-1676601
Abstract: BACKGROUND Surgical intervention has established a vital role in the management of chronic headaches. The lesser occipital nerve (LON) is a common target in patients suffering from occipital neuralgia and is often resected as a… read more here.
Keywords: lon; occipital nerve; mastoid prominence; identification ... See more keywords
Lon recognition of the replication initiator DnaA requires a bipartite degron
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Microbiology"
DOI: 10.1111/mmi.14146
Abstract: DnaA initiates chromosome replication in bacteria. In Caulobacter crescentus, the Lon protease degrades DnaA to coordinate replication with nutrient availability and to halt the cell cycle during acute stress. Here, we characterize the mechanism of… read more here.
Keywords: lon; degradation; lon recognition; replication ... See more keywords
Lon protease downregulates phenazine‐1‐carboxamide biosynthesis by degrading the quorum sensing signal synthase PhzI and exhibits negative feedback regulation of Lon itself in Pseudomonas chlororaphis HT66
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Microbiology"
DOI: 10.1111/mmi.14764
Abstract: Pseudomonas chlororaphis HT66 exhibits strong antagonistic activity against various phytopathogenic fungi due to its main antibiotic phenazine‐1‐carboxamide (PCN). PCN gene cluster consists of phzABCDEFG, phzH, phzI, and phzR operons. phzABCDEFG transcription is activated by the… read more here.
Keywords: lon; biosynthesis; chlororaphis ht66; pcn ... See more keywords
Structural basis for distinct operational modes and protease activation in AAA+ protease Lon
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba8404
Abstract: Substrate-free and -bound states of Lon reveal distinct operational modes used by the enzyme to process protein substrates. Substrate-bound structures of AAA+ protein translocases reveal a conserved asymmetric spiral staircase architecture wherein a sequential ATP… read more here.
Keywords: operational modes; lon; aaa protease; distinct operational ... See more keywords
Highly Contingent Phenotypes of Lon Protease Deficiency in Escherichia coli upon Antibiotic Challenge
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bacteriology"
DOI: 10.1128/jb.00561-19
Abstract: Understanding the evolutionary dynamics of antimicrobial resistance is vital to curb its emergence and spread. Being fundamentally similar to natural selection, the fitness of resistant mutants is a key parameter to consider in the evolutionary… read more here.
Keywords: lon; drug; highly contingent; deficiency ... See more keywords