Importance of The Mitochondrial Lon Protease in Age- and Sex-Specific Adaptation to Oxidative Stress
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.049
Abstract: The Lon protease plays a key role in mitochondrial proteostasis. We find that young female D. melanogaster flies, but not males, adapt to very low and non-damaging (micromolar), signaling, levels of H2O2 through the CncC… read more here.
Keywords: lon; medicine; age; specific adaptation ... See more keywords
Construction of Mitochondrial Protection and Monitoring Model of Lon Protease Based on Machine Learning under Myocardial Ischemia Environment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Environmental and Public Health"
DOI: 10.1155/2022/4805009
Abstract: The localization of a protein's submitochondrial structure is important for therapeutic design of associated disorders caused by mitochondrial abnormalities because many human diseases are directly tied to mitochondria. When Lon protease expression changes, glycolysis replaces… read more here.
Keywords: mitochondrial protection; protease based; lon protease; model lon ... See more keywords
Role of the Inserted α-Helical Domain in E. coli ATP-Dependent Lon Protease Function
Sign Up to like & getrecommendations! Published in 2017 at "Acta Naturae"
DOI: 10.32607/20758251-2017-9-2-75-81
Abstract: Multidomain ATP-dependent Lon protease of E. coli (Ec-Lon) is one of the key enzymes of the quality control system of the cellular proteome. A recombinant form of Ec-Lon with deletion of the inserted characteristic α-helical… read more here.
Keywords: lon; dependent lon; atp dependent; lon protease ... See more keywords
Structure, Substrate Specificity and Role of Lon Protease in Bacterial Pathogenesis and Survival
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043422
Abstract: Proteases are the group of enzymes that carry out proteolysis in all forms of life and play an essential role in cell survival. By acting on specific functional proteins, proteases affect the transcriptional and post-translational… read more here.
Keywords: lon protease; structure substrate; substrate specificity; bacterial pathogenesis ... See more keywords